sncb synuclein, beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sncbprovided by ZNC
Official Full Name: synuclein, betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1615
See related: Ensembl:ENSDARG00000104945 AllianceGenome:ZFIN:ZDB-GENE-040426-1615
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66343
Summary: Predicted to enable cuprous ion binding activity. Acts upstream of or within dopaminergic neuron differentiation and larval locomotory behavior. Predicted to be active in axon terminus; cytoplasm; and neuronal cell body. Is expressed in basal plate midbrain region; nervous system; pleuroperitoneal region; and trigeminal placode. Human ortholog(s) of this gene implicated in Lewy body dementia and Parkinson's disease. Orthologous to human SNCB (synuclein beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (50770537..50804042)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (45619305..45652810)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pla2g6 deficiency resulted in axonal degeneration, dopaminergic and motor neuron cell loss, and increased beta-synuclein expression.
Title: Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways.
Hypokinesia and reduced dopamine levels in zebrafish lacking beta- and gamma1-synucleins.
Title: Hypokinesia and reduced dopamine levels in zebrafish lacking β- and γ1-synucleins.
Data show the sequences of zebrafish synucleins are very similar to those of the human proteins. Whole-mount in situ hybridization show that sncb were expressed strongly in the nervous system.
Title: Discovery and characterization of three novel synuclein genes in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fj45h11.x1 (e-PCR)
- UniSTS:199393

fj16g07.x1 (e-PCR)
- UniSTS:198645

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cuprous ion binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dopaminergic neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: beta-synuclein

Names: zSyn-&beta; zSynC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.