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    mtap methylthioadenosine phosphorylase [ Danio rerio (zebrafish) ]

    Gene ID: 393526, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mtapprovided by ZNC
    Official Full Name
    methylthioadenosine phosphorylaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1505
    See related
    Ensembl:ENSDARG00000037261 AllianceGenome:ZFIN:ZDB-GENE-040426-1505
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66012
    Summary
    Predicted to enable S-methyl-5-thioadenosine phosphorylase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to act upstream of or within purine ribonucleoside salvage. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mtap in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (26111024..26127939)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (25417310..25434225)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B Neighboring gene topoisomerase I binding, arginine/serine-rich a Neighboring gene cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4) Neighboring gene CXXC finger 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of zebrafish (Danio rerio) infected with infectious spleen and kidney necrosis virus. Xiong XP, et al. Dev Comp Immunol, 2011 Apr. PMID 21075138
    2. Proteomics of early zebrafish embryos. Link V, et al. BMC Dev Biol, 2006 Jan 13. PMID 16412219, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66012

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables S-methyl-5-thioadenosine phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-methyl-5-thioadenosine phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    S-methyl-5'-thioadenosine phosphorylase
    NP_956848.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200554.1 → NP_956848.1  S-methyl-5'-thioadenosine phosphorylase

      See identical proteins and their annotated locations for NP_956848.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056545
      UniProtKB/Swiss-Prot
      Q6PHI0, Q7ZV22
      UniProtKB/TrEMBL
      B2GQM6
      Related
      ENSDARP00000054207.6, ENSDART00000054208.8
      Conserved Domains (2) summary
      COG0005
      Location:7 → 255
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      cl00303
      Location:7 → 255
      PNP_UDP_1; Phosphorylase superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      26111024..26127939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZV22.2 GenPept UniProtKB/Swiss-Prot:Q7ZV22

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