ggt1a gamma-glutamyltransferase 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ggt1aprovided by ZNC
Official Full Name: gamma-glutamyltransferase 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1388
See related: Ensembl:ENSDARG00000023526 AllianceGenome:ZFIN:ZDB-GENE-040426-1388
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ggt1; zgc:64172
Summary: Predicted to enable glutathione hydrolase activity and leukotriene C4 gamma-glutamyl transferase activity. Predicted to act upstream of or within glutathione catabolic process. Predicted to be located in membrane. Is expressed in lens and solid lens vesicle. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (40042632..40075983, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (40008716..40042209, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables leukotriene C4 gamma-glutamyl transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glutathione catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gamma-glutamyltransferase 1a

Names: gamma-glutamyltransferase 1

NP_956709.1

EC 2.3.2.2

XP_017212782.1

EC 2.3.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200415.1 → NP_956709.1 gamma-glutamyltransferase 1a

Status: PROVISIONAL

Source sequence(s)

BC054631

UniProtKB/TrEMBL

A0A8N7V022, Q7T2A1

Related

ENSDARP00000037959.4, ENSDART00000036280.5

Conserved Domains (1) summary

pfam01019
Location:1 → 484

G_glu_transpept; Gamma-glutamyltranspeptidase