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    rad18 RAD18 E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

    Gene ID: 393106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rad18provided by ZNC
    Official Full Name
    RAD18 E3 ubiquitin protein ligaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-745
    See related
    Ensembl:ENSDARG00000027938 AllianceGenome:ZFIN:ZDB-GENE-040426-745
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55577
    Summary
    Predicted to enable metal ion binding activity; single-stranded DNA binding activity; and ubiquitin protein ligase activity. Predicted to be involved in postreplication repair and protein monoubiquitination. Predicted to act upstream of or within DNA repair. Predicted to be part of Rad6-Rad18 complex. Predicted to be active in nucleus. Orthologous to human RAD18 (RAD18 E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rad18 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (41808694..41887398)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (41811137..41890128)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene SLIT-ROBO Rho GTPase activating protein 3 Neighboring gene uncharacterized LOC137495888 Neighboring gene uncharacterized LOC137496000 Neighboring gene oxytocin receptor a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The cytotoxicity and genotoxicity of single and combined fenthion and terbufos treatments in human liver cells and zebrafish embryos. Wahyuni EA, et al. Sci Total Environ, 2021 Mar 1. PMID 33221015
    2. Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. Shin U, et al. DNA Repair (Amst), 2021 Nov. PMID 34390914
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55577

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within postreplication repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Rad6-Rad18 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RAD18
    Names
    RAD18 homolog
    NP_956431.1
    XP_009300817.1
    XP_068077765.1
    XP_068077766.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200137.1 → NP_956431.1  E3 ubiquitin-protein ligase RAD18

      See identical proteins and their annotated locations for NP_956431.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044430
      UniProtKB/TrEMBL
      Q803L3
      Related
      ENSDARP00000035402.5, ENSDART00000038163.7
      Conserved Domains (4) summary
      smart00734
      Location:197 → 220
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:25 → 65
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13 → 356
      rad18; DNA repair protein rad18
      pfam02037
      Location:243 → 276
      SAP; SAP domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      41808694..41887398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302542.4 → XP_009300817.1  E3 ubiquitin-protein ligase RAD18 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B0K8
      Conserved Domains (4) summary
      smart00734
      Location:197 → 220
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:25 → 65
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13 → 356
      rad18; DNA repair protein rad18
      pfam02037
      Location:243 → 276
      SAP; SAP domain

    2. XM_068221665.1 → XP_068077766.1  E3 ubiquitin-protein ligase RAD18 isoform X3

    3. XM_068221664.1 → XP_068077765.1  E3 ubiquitin-protein ligase RAD18 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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