ERR estrogen-related receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ERRprovided by FlyBase
Official Full Name: estrogen-related receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0035849
Locus tag: Dmel_CG7404
See related: AllianceGenome:FB:FBgn0035849
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7404; dERR; Derr; Dmel\CG7404; NR3B4
Summary: Predicted to enable estrogen response element binding activity and nuclear receptor activity. Involved in regulation of transcription by RNA polymerase II and spermatogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in anterior midgut primordium; embryonic midgut chamber; embryonic/larval midgut; organism; and posterior midgut primordium. Used to study azoospermia and cancer. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 35. Orthologous to several human genes including ESRRA (estrogen related receptor alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 66B11-66B11; 3-22 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8183361..8186671, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8176461..8179771, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of glucocorticoid receptor in Drosophila melanogaster.
Title: Identification of glucocorticoid receptor in Drosophila melanogaster.
Drosophila estrogen-related receptor directs a transcriptional switch that supports adult glycolysis and lipogenesis.
Title: Drosophila estrogen-related receptor directs a transcriptional switch that supports adult glycolysis and lipogenesis.
These findings add newer dimensions to the functions envisaged for ERR and provide the foundation for deciphering the relevance of orphan nuclear receptors in ciliopathies and testicular dysgenesis.
Title: Estrogen related receptor is required for the testicular development and for the normal sperm axoneme/mitochondrial derivatives in Drosophila males.
Expression levels of estrogen-related receptor gene (ERR), ecdysone receptor gene (EcR) and Yolk protein receptor gene (YPR) were significantly changed by ethylparaben treatment. Female fruit flies are more sensitive to EP than males.
Title: Ethylparaben affects lifespan, fecundity, and the expression levels of ERR, EcR and YPR in Drosophila melanogaster.
These results indicate that competent hypoxic responses arise from complex interactions between HIF-dependent and -independent mechanisms, and that dERR plays a central role in both of these programs.
Title: HIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogaster.
The estrogen-related receptor plays a central role in carbohydrate metabolism, demonstrates that a proliferative metabolic program is used in normal developmental growth
Title: The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth.
characterization of ligand binding pocket of ERR
Title: A triple mutant of the Drosophila ERR confers ligand-induced suppression of activity.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: estrogen-related receptor

Names: CG7404-PA; CG7404-PB; ERR-PA; ERR-PB; Estrogen-Related receptor; estrogen receptor; estrogen related receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8183361..8186671 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168258.3 → NP_729340.1 estrogen-related receptor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729340.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VSE9

Related

FBpp0076447

Conserved Domains (2) summary

cd07170
Location:109 → 205

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

cl11397
Location:225 → 481

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_139926.3 → NP_648183.3 estrogen-related receptor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648183.3

Status: REVIEWED

UniProtKB/TrEMBL

Q8WS79

Related

FBpp0076448

Conserved Domains (2) summary

cd07170
Location:121 → 217

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

cl11397
Location:237 → 493

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators