pav pavarotti [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pavprovided by FlyBase
Official Full Name: pavarottiprovided by FlyBase
Primary source: FLYBASE:FBgn0011692
Locus tag: Dmel_CG1258
See related: AllianceGenome:FB:FBgn0011692
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0934/13; 0973/08; 2A12; 2A12MEL; anon-EST:fe2A12; anon2A12; CG1258; Dmel\CG1258; DmKLP1/pav; DmMKLP1; DmPav; DmPAV; group D; KIF 23; KIF23; kinesin-6; Mklp1; MKLP1; Pav; PAV; Pav KLP; pav-Klp; pav-KLP; Pav-klp; Pav-Klp; Pav-KLP; PAV-KLP; PAV-MKLP; PAV/KLP; PavKLP
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; larval somatic muscle development; and negative regulation of canonical Wnt signaling pathway. Located in several cellular components, including male germline ring canal; somatic ring canal; and spindle. Part of centralspindlin complex. Is expressed in several structures, including embryonic central brain glial cell; ganglia; germline cell; head epidermis primordium; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type III. Orthologous to human KIF23 (kinesin family member 23). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64A10-64A11; 3-10 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4242734..4246233)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4242734..4246233)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Centralspindlin proteins Pavarotti and Tumbleweed along with WASH regulate nuclear envelope budding.
Title: Centralspindlin proteins Pavarotti and Tumbleweed along with WASH regulate nuclear envelope budding.
elevated expression of Pav-KLP underlies transport and plasticity phenotypes in pathway mutants, indicating that Toll-6-FoxO signaling promotes MT dynamics by limiting Pav-KLP expression.
Title: A Toll receptor-FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons.
Data show that GTPase-activating protein (Tum/RacGAP) is required for the motor activity of kinesin-6 motor (Pav/kinesin-6).
Title: Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor.
Depletion of Pav-KLP in neurons strongly stimulated kinesin-1-driven sliding of long microtubules and neurite outgrowth, while its ectopic overexpression in the cytoplasm blocked both of these processes.
Title: Pavarotti/MKLP1 regulates microtubule sliding and neurite outgrowth in Drosophila neurons.
Study demonstrates the emerging role of centralspindlin (complex of two proteins Tum and Pav) in regulating cell migration and cell adhesion in addition to its previously known function during cytokinesis.
Title: Centralspindlin is required for thorax development during Drosophila metamorphosis.
Data show that Sticky (Sti), tile ring component Citron kinase (CIT-K) interacts directly with two kinesins, Nebbish and Pavarotti and that in turn these kinesins interact with each other and with another central spindle protein, Fascetto.
Title: Citron kinase controls a molecular network required for midbody formation in cytokinesis.
Results identify two modulators of the Wnt pathway, Tum and Pav, that have shared functions in cell division, which hints at a possible link between cytokinesis and Wnt activity during tumorigenesis.
Title: Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation.
Pav-KLP transports elements of the actomyosin cytoskeleton
Title: Localization of Pavarotti-KLP in living Drosophila embryos suggests roles in reorganizing the cortical cytoskeleton during the mitotic cycle.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actomyosin contractile ring contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval somatic muscle development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maintenance of protein location in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule sliding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
part_of centralspindlin complex	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in contractile ring	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in female germline ring canal	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in male germline ring canal	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in somatic ring canal	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pavarotti

Names: CG1258-PA; Kinesin-6; Kinesin6; Pavarotti-KLP; anon-fast-evolving-2A12; mitotic kinesin-like protein 1; pav-PA; pavarotti KLP; pavarotti kinesin-like protein; pavarroti

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

4242734..4246233

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057677.4 → NP_477025.1 pavarotti [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477025.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SXT9, Q9VZF5

Related

FBpp0073083

Conserved Domains (3) summary

cd01368
Location:35 → 450

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:42 → 452

Kinesin; Kinesin motor domain

pfam16540
Location:735 → 837

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1