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    Tvp23a trans-golgi network vesicle protein 23A [ Mus musculus (house mouse) ]

    Gene ID: 383103, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tvp23aprovided by MGI
    Official Full Name
    trans-golgi network vesicle protein 23Aprovided by MGI
    Primary source
    MGI:MGI:3665441
    See related
    Ensembl:ENSMUSG00000050908 AllianceGenome:MGI:3665441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam18a
    Summary
    Predicted to be involved in protein secretion and vesicle-mediated transport. Predicted to be active in Golgi membrane. Orthologous to human TVP23A (trans-golgi network vesicle protein 23 homolog A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 13.8), CNS E18 (RPKM 13.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tvp23a in Genome Data Viewer
    Location:
    16 A1; 16 5.61 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10237397..10265251, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10419533..10447390, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30724 Neighboring gene tektin 5 Neighboring gene predicted gene, 41419 Neighboring gene STARR-positive B cell enhancer ABC_E10886 Neighboring gene nucleotide binding protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10469529-10469712 Neighboring gene STARR-seq mESC enhancer starr_40087 Neighboring gene predicted gene, 41420 Neighboring gene STARR-positive B cell enhancer mm9_chr16:10487992-10488292 Neighboring gene class II transactivator Neighboring gene predicted gene, 57630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases. Bussink AP, et al. Genetics, 2007 Oct. PMID 17720922, Free PMC Article
    2. RREB1 regulates neuronal proteostasis and the microtubule network. Griffin EN, et al. Sci Adv, 2024 Jan 12. PMID 38198538, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Golgi apparatus membrane protein TVP23 homolog A
    Names
    family with sequence similarity 18, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013778.2 → NP_001013800.1  Golgi apparatus membrane protein TVP23 homolog A isoform 1

      See identical proteins and their annotated locations for NP_001013800.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC122352
      Consensus CDS
      CCDS27949.1
      UniProtKB/TrEMBL
      Q6NVH0
      Related
      ENSMUSP00000052922.7, ENSMUST00000051118.7
      Conserved Domains (1) summary
      pfam05832
      Location:39 → 180
      DUF846; Eukaryotic protein of unknown function (DUF846)

    2. NM_001359069.1 → NP_001345998.1  Golgi apparatus membrane protein TVP23 homolog A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a alternate AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC122352
      Conserved Domains (1) summary
      pfam05832
      Location:30 → 171
      DUF846; Eukaryotic protein of unknown function (DUF846)

    3. NM_001429122.1 → NP_001416051.1  Golgi apparatus membrane protein TVP23 homolog A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122352

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      10237397..10265251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522315.5 → XP_006522378.1  Golgi apparatus membrane protein TVP23 homolog A isoform X2

      Conserved Domains (1) summary
      pfam05832
      Location:30 → 189
      DUF846; Eukaryotic protein of unknown function (DUF846)

    2. XM_006522314.5 → XP_006522377.1  Golgi apparatus membrane protein TVP23 homolog A isoform X1

      Conserved Domains (1) summary
      pfam05832
      Location:39 → 198
      DUF846; Eukaryotic protein of unknown function (DUF846)
    Nucleotide Protein Strain
    Heading Accession and Version

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