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    Mrgpra6 MAS-related GPR, member A6 [ Mus musculus (house mouse) ]

    Gene ID: 381886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrgpra6provided by MGI
    Official Full Name
    MAS-related GPR, member A6provided by MGI
    Primary source
    MGI:MGI:3033107
    See related
    AllianceGenome:MGI:3033107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MrgA6
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human MRGPRX4 (MAS related GPR family member X4). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
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    Genomic context

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    See Mrgpra6 in Genome Data Viewer
    Location:
    7 B3; 7 30.74 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46835465..46839164, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (47185717..47189416, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 5 Neighboring gene microRNA 7056 Neighboring gene STARR-seq mESC enhancer starr_18879 Neighboring gene STARR-positive B cell enhancer ABC_E4928 Neighboring gene predicted gene 14377 Neighboring gene STARR-seq mESC enhancer starr_18880 Neighboring gene STARR-positive B cell enhancer mm9_chr7:54405971-54406272 Neighboring gene MAS-related GPR, member A1 pseudogene Neighboring gene MAS-related GPR, member A9 Neighboring gene STARR-seq mESC enhancer starr_18881

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Han SK, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12397184, Free PMC Article
    2. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Dong X, et al. Cell, 2001 Sep 7. PMID 11551509
    3. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12909716, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mas-related G-protein coupled receptor member A6
    Names
    MrgA6 G protein-coupled receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308537.1 → NP_001295466.1  mas-related G-protein coupled receptor member A6

      See identical proteins and their annotated locations for NP_001295466.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding allele found in the 129X1/SvJ strain genome.
      Source sequence(s)
      BC132198
      UniProtKB/Swiss-Prot
      A3KMK5, E9QN26, Q91ZC6
      Conserved Domains (1) summary
      pfam00001
      Location:26 → 258
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RNA

    1. NR_131899.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents a putative transcript from the reference genome. The reference genome contains mismatches and a large insertion of a retrotransposable element relative to other strain genomes. These differences result in early termination of the open reading frame found in variant 1. This variant may not be transcribed.
      Source sequence(s)
      AC115898

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      46835465..46839164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_205821.2: Suppressed sequence

      Description
      NM_205821.2: This RefSeq was removed because currently there is insufficient support for the protein.

    2. NR_131897.1: Suppressed sequence

      Description
      NR_131897.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZC6.2 GenPept UniProtKB/Swiss-Prot:Q91ZC6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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