Hipk Homeodomain interacting protein kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hipkprovided by FlyBase
Official Full Name: Homeodomain interacting protein kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0035142
Locus tag: Dmel_CG17090
See related: AllianceGenome:FB:FBgn0035142
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17090; dhipk2; DHIPK2; Dmel\CG17090; hipk; hipK; HipK; HIPK; HIPK2
Summary: Enables DNA-binding transcription factor binding activity; beta-catenin binding activity; and protein serine/threonine kinase activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; protein stabilization; and regulation of signal transduction. Located in nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; eye disc anterior to the morphogenetic furrow; ganglia; imaginal disc; and somatic cell of testis. Used to study cancer. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 61C3-61C5; 3-0.5 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (543060..581099)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (543060..581099)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the effects of altered Hipk expression on the nervous system and muscle, are reported.
Title: Homeodomain-interacting protein kinase (Hipk) plays roles in nervous system and muscle structure and function.
The authors present novel evidence that Hipk is a regulator of the JAK/STAT pathway.
Title: Hipk is required for JAK/STAT activity during development and tumorigenesis.
The phosphorylation of Hbn, Ems, and Msh may provide further insight into the function of Hipk during development of the Drosophila nervous system.
Title: Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Homeodomain Proteins Homeobrain, Empty Spiracles, and Muscle Segment Homeobox.
levels of Hipk on their own can promote both hyperproliferation and invasive cell behavior, suggesting that Hipk family members could be potent oncogenes and drivers of epithelial-to-mesenchymal transition .
Title: Homeodomain-interacting protein kinase promotes tumorigenesis and metastatic cell behavior.
This study set Hipk and the master regulators Toy and Ey in an enzyme-substrate relationship. The interaction and phosphorylation of the master regulator Toy by Hipk may be important for precise tuning of signalling within the retinal determination gene network and therefore for Drosophila eye development.
Title: Homeodomain-interacting protein kinase phosphorylates the Drosophila Paired box protein 6 (Pax6) homologues Twin of eyeless and Eyeless.
Data indicate that Hipk as a repressor of both Twin of eyeless (Toy) and Eyeless (Ey).
Title: Hipk promotes photoreceptor differentiation through the repression of Twin of eyeless and Eyeless expression.
A role for Hipk in the Hippo pathway.
Title: A role for Hipk in the Hippo pathway.
Hipk proteins have a role independent of their effect on beta-catenin/Armadillo stability to enhance Wnt/Wingless signaling.
Title: Hipk proteins dually regulate Wnt/Wingless signal transduction.
Data show that Hipk dually regulates both Wingless and Hedgehog signaling by impeding the function of the E3 ubiquitin ligase complex, thereby inhibiting Armadillo ubiquitination and subsequent degradation.
Title: Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling.
demonstrate that Hipk is sumolylated in vivo, and its nuclear localization is dependent on the sumoylation pathway
Title: Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1938 (e-PCR)
- UniSTS:73119

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gravitaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of programmed cell death	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeodomain interacting protein kinase

Names: CG17090-PA; CG17090-PB; CG17090-PC; CG17090-PD; Hipk-PA; Hipk-PB; Hipk-PC; Hipk-PD; Homeodomain-interacting protein kinase; Homeodomain-interacting protein kinase 2; homeodomain interactin protein kinase

NP_001261215.1

EC 2.7.11.1

NP_001369036.1

EC 2.7.11.1

NP_612038.2

EC 2.7.11.1

NP_728531.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

543060..581099

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167834.2 → NP_728531.1 homeodomain interacting protein kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728531.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0D4RSJ1, Q9W0Q1

Related

FBpp0072450

Conserved Domains (2) summary

smart00220
Location:192 → 519

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14211
Location:192 → 520

STKc_HIPK; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase
NM_001382035.1 → NP_001369036.1 homeodomain interacting protein kinase, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0D4RSJ1, A0A6M3Q6U2

Conserved Domains (2) summary

PHA03378
Location:1080 → 1327

PHA03378; EBNA-3B; Provisional

cd14211
Location:192 → 520

STKc_HIPK; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase
NM_138194.3 → NP_612038.2 homeodomain interacting protein kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_612038.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0D4RSJ1, Q9W0Q1

Related

FBpp0072451

Conserved Domains (2) summary

smart00220
Location:192 → 519

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14211
Location:192 → 520

STKc_HIPK; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase
NM_001274286.1 → NP_001261215.1 homeodomain interacting protein kinase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261215.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0D4RSJ1, M9PDR2

Conserved Domains (2) summary

smart00220
Location:108 → 435

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14211
Location:108 → 436

STKc_HIPK; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase