dnr1 defense repressor 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dnr1provided by FlyBase
Official Full Name: defense repressor 1provided by FlyBase
Primary source: FLYBASE:FBgn0260866
Locus tag: Dmel_CG12489
See related: AllianceGenome:FB:FBgn0260866
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12489; Dmel\CG12489; Dnr-1; dNR1; Dnr1; DNR1; Mylip
Summary: Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in negative regulation of defense response to bacterium; proteasome-mediated ubiquitin-dependent protein catabolic process; and sleep. Predicted to be located in cytoskeleton. Is expressed in several structures, including antennal primordium; central brain primordium; head epidermis primordium; midline primordium; and ventral ectoderm. Used to study neurodegenerative disease. Orthologous to human MYLIP (myosin regulatory light chain interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22563152..22592964, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18450657..18480469, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of antibacterial peptide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

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