U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    tpr tracheal-prostasin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37486, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tprprovided by FlyBase
    Official Full Name
    tracheal-prostasinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034661
    Locus tag
    Dmel_CG4386
    See related
    AllianceGenome:FB:FBgn0034661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4386; Dmel\CG4386; SP17; Tpr
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in liquid clearance, open tracheal system. Predicted to be active in extracellular space. Is expressed in embryonic/larval dorsal tracheal branch; embryonic/larval tracheal dorsal trunk; and embryonic/larval visceral tracheal branch. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tpr in Genome Data Viewer
    Location:
    58A1-58A1; 2-97 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21799330..21800904, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17686835..17688409, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR9284 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis. Drees L, et al. PLoS Genet, 2019 Jan. PMID 30601807, Free PMC Article
    2. Genomic analysis of Drosophila chromosome underreplication reveals a link between replication control and transcriptional territories. Belyakin SN, et al. Proc Natl Acad Sci U S A, 2005 Jun 7. PMID 15928082, Free PMC Article
    3. Helena and BS: Two Travellers between the Genera Drosophila and Zaprionus. Simão MC, et al. Genome Biol Evol, 2018 Oct 1. PMID 30165545, Free PMC Article
    4. Transcriptional activation in Drosophila spermatogenesis involves the mutually dependent function of aly and a novel meiotic arrest gene cookie monster. Jiang J, et al. Development, 2003 Feb. PMID 12490562
    5. Form and function of the apical extracellular matrix: new insights from Caenorhabditis elegans, Drosophila melanogaster, and the vertebrate inner ear. Li Zheng S, et al. Fac Rev, 2020. PMID 33659959, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tracheal-prostasin
    Names
    CG4386-PA
    tpr-PA
    NP_611611.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21799330..21800904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137767.4 → NP_611611.1  tracheal-prostasin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2C8
      Related
      FBpp0071657
      Conserved Domains (2) summary
      smart00020
      Location:126 → 354
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:127 → 356
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2C8 Q9W2C8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools