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    Sdc Syndecan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sdcprovided by FlyBase
    Official Full Name
    Syndecanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010415
    Locus tag
    Dmel_CG10497
    See related
    AllianceGenome:FB:FBgn0010415
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10497; CT27296; Dmel\CG10497; dSdc; Dsyn; l(2)10608; sdc; syd; Syd; syn; Syn
    Summary
    Involved in epithelial cell migration, open tracheal system; neurogenesis; and positive regulation of synaptic assembly at neuromuscular junction. Located in axon and neuromuscular junction. Is expressed in several structures, including gut section; head epidermis primordium; mesoderm; tract; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in cleft lip; cleft palate; and obesity. Orthologous to several human genes including SDC1 (syndecan 1) and SDC4 (syndecan 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Sdc in Genome Data Viewer
    Location:
    57E1-57E6; 2-95 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21392402..21481176, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17279907..17368681, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A oxidase at 57D proximal Neighboring gene eukaryotic translation elongation factor, selenocysteine-specific Neighboring gene acyl-Coenzyme A oxidase at 57D distal Neighboring gene Smad anchor for receptor activation Neighboring gene FK506-binding protein 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila syndecan: conservation of a cell-surface heparan sulfate proteoglycan. Spring J, et al. Proc Natl Acad Sci U S A, 1994 Apr 12. PMID 8159748, Free PMC Article
    2. A novel method for tissue-specific RNAi rescue in Drosophila. Schulz JG, et al. Nucleic Acids Res, 2009 Jul. PMID 19483100, Free PMC Article
    3. Functional characterization of Drosophila melanogaster peptide O-xylosyltransferase, the key enzyme for proteoglycan chain initiation and member of the core 2/I N-acetylglucosaminyltransferase family. Wilson IB. J Biol Chem, 2002 Jun 14. PMID 11929872
    4. Heparan sulfate proteoglycan molecules, syndecan and perlecan, have distinct roles in the maintenance of Drosophila germline stem cells. Hayashi Y, et al. Dev Growth Differ, 2021 Aug. PMID 34324711
    5. The heparan sulfate proteoglycans Dally-like and Syndecan have distinct functions in axon guidance and visual-system assembly in Drosophila. Rawson JM, et al. Curr Biol, 2005 May 10. PMID 15886101

    See all (152) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. all detectable Sdc found at the NMJ is provided by the muscle, strongly suggesting a post-synaptic role for Sdc. both the cytoplasmic and extracellular domains of Sdc are required to promote synapse growth or to rescue Sdc loss of function.
      Title: The Extracellular and Cytoplasmic Domains of Syndecan Cooperate Postsynaptically to Promote Synapse Growth at the Drosophila Neuromuscular Junction.
    2. We conclude that Sdc cell autonomously regulates Slit/Robo2 signalling in tracheal cells to guarantee ordered directional migration and branch fusion.
      Title: Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels.
    3. In this study, we provide evidence that Dlp and Sdc have both overlapping and distinct functions in axon guidance and in defining accurate patterns of axonal fasciculation within the lateral CNS neuropil
      Title: Heparan sulfate proteoglycan specificity during axon pathway formation in the Drosophila embryo.
    4. Syndecan acting as a co-receptor for Slit in the Drosophila heart.
      Title: Syndecan contributes to heart cell specification and lumen formation during Drosophila cardiogenesis.
    5. Dlp, which lacks chondroitin sulfate (CS)modifications, participates in the transfer of Slit from its site of expression to the target cells, where CS-modified Sdc concentrates and presents the ligand.
      Title: Reception of Slit requires only the chondroitin-sulphate-modified extracellular domain of Syndecan at the target cell surface.
    6. Syndecan (Sdc) is critical for the fidelity of Slit repellent signaling at the midline of the Drosophila CNS.
      Title: Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance.
    7. The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase.
      Title: The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in perivitelline space HDA PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    syndecan
    Names
    CG10497-PA
    CG10497-PB
    CG10497-PD
    CG10497-PG
    CG10497-PH
    CG10497-PI
    CG10497-PJ
    CG10497-PK
    CG10497-PL
    Sdc-PA
    Sdc-PB
    Sdc-PD
    Sdc-PG
    Sdc-PH
    Sdc-PI
    Sdc-PJ
    Sdc-PK
    Sdc-PL
    dSyndecan

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21392402..21481176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166450.3 → NP_726072.2  syndecan, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726072.2

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam01034
      Location:256 → 320
      Syndecan; Syndecan domain

    2. NM_001144257.4 → NP_001137729.2  syndecan, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137729.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZN0
      Conserved Domains (1) summary
      pfam01034
      Location:428 → 492
      Syndecan; Syndecan domain

    3. NM_001259518.2 → NP_001246447.1  syndecan, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246447.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K862
      Conserved Domains (1) summary
      pfam01034
      Location:9 → 73
      Syndecan; Syndecan domain

    4. NM_001369961.1 → NP_001356968.1  syndecan, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4P7VJV5
      Conserved Domains (1) summary
      pfam01034
      Location:333 → 397
      Syndecan; Syndecan domain

    5. NM_057617.5 → NP_476965.1  syndecan, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476965.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49415, Q0E8Z8, Q8SXJ0, Q9W2G7
      Related
      FBpp0071623
      Conserved Domains (1) summary
      pfam01034
      Location:333 → 397
      Syndecan; Syndecan domain

    6. NM_001169767.3 → NP_001163238.2  syndecan, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163238.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGQ9
      Conserved Domains (1) summary
      pfam01034
      Location:429 → 493
      Syndecan; Syndecan domain

    7. NM_166449.5 → NP_726071.1  syndecan, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726071.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49415
      Related
      FBpp0071624
      Conserved Domains (2) summary
      pfam01034
      Location:160 → 224
      Syndecan; Syndecan domain
      NF033845
      Location:55 → 202
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    8. NM_001299749.1 → NP_001286678.1  syndecan, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286678.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG79
      Conserved Domains (1) summary
      pfam01034
      Location:200 → 264
      Syndecan; Syndecan domain

    9. NM_001144256.2 → NP_001137728.1  syndecan, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137728.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZM9
      Conserved Domains (1) summary
      pfam01034
      Location:332 → 396
      Syndecan; Syndecan domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K862 A0A0B4K862
    A0A0B4LG79 A0A0B4LG79
    A0A4P7VJV5 A0A4P7VJV5
    B7YZM9 B7YZM9
    B7YZN0 B7YZN0
    E1JGQ9 E1JGQ9
    P49415.2 P49415

    Gene LinkOut

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