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    Isha Insulator su(Hw) mRNA adaptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37411, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ishaprovided by FlyBase
    Official Full Name
    Insulator su(Hw) mRNA adaptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034598
    Locus tag
    Dmel_CG4266
    See related
    AllianceGenome:FB:FBgn0034598
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg4266; CG4266; Dmel\CG4266
    Summary
    Enables chromatin binding activity and mRNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin. Is expressed in larval ventral nerve cord and organism. Orthologous to human SCAF4 (SR-related CTD associated factor 4) and SCAF8 (SR-related CTD associated factor 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Isha in Genome Data Viewer
    Location:
    57C6-57C7; 2-93 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21161713..21168659, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17049218..17056164, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glycine-GCC 1-12 Neighboring gene transfer RNA:Tryptophan-CCA 2-4 Neighboring gene hinge1 Neighboring gene Like Sm 1 Neighboring gene Xeroderma pigmentosum D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variants in SCAF4 Cause a Neurodevelopmental Disorder and Are Associated with Impaired mRNA Processing. Fliedner A, et al. Am J Hum Genet, 2020 Sep 3. PMID 32730804, Free PMC Article
    2. Isha is a su(Hw) mRNA-binding protein required for gypsy insulator function. Bag I, et al. G3 (Bethesda), 2022 Aug 25. PMID 35708663, Free PMC Article
    3. The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning. Hull R, et al. Int J Mol Sci, 2015 May 6. PMID 25955646, Free PMC Article
    4. The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy. Pogson JH, et al. PLoS Genet, 2014 Nov. PMID 25412178, Free PMC Article
    5. Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila. VoSSfeldt H, et al. PLoS One, 2012. PMID 23139745, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Variants in SCAF4 Cause a Neurodevelopmental Disorder and Are Associated with Impaired mRNA Processing.
      Title: Variants in SCAF4 Cause a Neurodevelopmental Disorder and Are Associated with Impaired mRNA Processing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    insulator su(Hw) mRNA adaptor
    Names
    CG4266-PA
    CG4266-PB
    CG4266-PC
    CG4266-PD
    Isha-PA
    Isha-PB
    Isha-PC
    Isha-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21161713..21168659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299735.1 → NP_001286664.1  insulator su(Hw) mRNA adaptor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286664.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH25
      Conserved Domains (5) summary
      COG0724
      Location:394 → 499
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd03562
      Location:7 → 125
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
      cd12227
      Location:396 → 472
      RRM_SCAF4_SCAF8; RNA recognition motif in SR-related and CTD-associated factor 4 (SCAF4), SR-related and CTD-associated factor 8 (SCAF8) and similar proteins
      pfam04929
      Location:1112 → 1210
      Herpes_DNAp_acc; Herpes DNA replication accessory factor
      pfam10310
      Location:1053 → 1160
      DUF2413; Protein of unknown function (DUF2413)

    2. NM_137713.3 → NP_611557.2  insulator su(Hw) mRNA adaptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611557.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2K4
      Related
      FBpp0071554
      Conserved Domains (5) summary
      COG0724
      Location:397 → 502
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd03562
      Location:7 → 125
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
      cd12227
      Location:399 → 475
      RRM_SCAF4_SCAF8; RNA recognition motif in SR-related and CTD-associated factor 4 (SCAF4), SR-related and CTD-associated factor 8 (SCAF8) and similar proteins
      pfam04929
      Location:1115 → 1213
      Herpes_DNAp_acc; Herpes DNA replication accessory factor
      pfam10310
      Location:1056 → 1163
      DUF2413; Protein of unknown function (DUF2413)

    3. NM_001274190.2 → NP_001261119.1  insulator su(Hw) mRNA adaptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261119.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2VEJ9
      Conserved Domains (1) summary
      cd03562
      Location:7 → 125
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...

    4. NM_001103924.2 → NP_001097394.1  insulator su(Hw) mRNA adaptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYK5
      Conserved Domains (5) summary
      COG0724
      Location:488 → 593
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd03562
      Location:7 → 125
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
      cd12227
      Location:490 → 566
      RRM_SCAF4_SCAF8; RNA recognition motif in SR-related and CTD-associated factor 4 (SCAF4), SR-related and CTD-associated factor 8 (SCAF8) and similar proteins
      pfam04929
      Location:1206 → 1304
      Herpes_DNAp_acc; Herpes DNA replication accessory factor
      pfam10310
      Location:1147 → 1254
      DUF2413; Protein of unknown function (DUF2413)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LH25 A0A0B4LH25
    A2VEJ9 A2VEJ9
    A8DYK5 A8DYK5
    Q95TR3 Q95TR3
    Q9W2K4 Q9W2K4

    Gene LinkOut

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