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    ctbp1.L C-terminal binding protein 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 373701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ctbp1.L
    Official Full Name
    C-terminal binding protein 1 L homeolog
    Primary source
    Xenbase:XB-GENE-864974
    Locus tag
    XELAEV_18005017mg
    See related
    EnsemblRapid:ENSXLAG00005020859 AllianceGenome:Xenbase:XB-GENE-864974
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    CtBP; ctbp1; ctbp-a; xctbp1; ctbp1-A
    Summary
    Predicted to enable several functions, including NAD binding activity; transcription coregulator activity; and transcription coregulator binding activity. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in nervous system; pharyngeal arch; and visual system. Orthologous to human CTBP1 (C-terminal binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ctbp1.L in Genome Data Viewer
    Location:
    chromosome: 1L
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (19811250..20173479, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (11013898..11155449, complement)

    Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene transmembrane emp24 domain-containing protein 11-like Neighboring gene spondin 2, extracellular matrix protein L homeolog Neighboring gene uncharacterized LOC108696303 Neighboring gene macrophage erythroblast attacher L homeolog Neighboring gene UV stimulated scaffold protein A L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. Sewalt RG, et al. Mol Cell Biol, 1999 Jan. PMID 9858600, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    C-terminal-binding protein 1
    Names
    C-terminal-binding protein A
    NP_001079151.1
    XP_018110185.1
    XP_018110345.1
    XP_041442837.1
    XP_041442870.1
    XP_041443001.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085682.1 → NP_001079151.1  C-terminal-binding protein 1

      See identical proteins and their annotated locations for NP_001079151.1

      Status: PROVISIONAL

      Source sequence(s)
      AF091554
      UniProtKB/Swiss-Prot
      Q9YHU0
      Related
      ENSXLAP00005061275.1, ENSXLAT00005062727.1
      Conserved Domains (2) summary
      COG0111
      Location:55 → 354
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd05299
      Location:28 → 346
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      19811250..20173479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041586903.1 → XP_041442837.1  C-terminal-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8J1MM82
      Related
      ENSXLAP00005061296.1, ENSXLAT00005062747.1
      Conserved Domains (1) summary
      cd05299
      Location:67 → 385
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    2. XM_018254856.2 → XP_018110345.1  C-terminal-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8J0UVK5
      Related
      ENSXLAP00005061286.1, ENSXLAT00005062738.1

    3. XM_018254696.2 → XP_018110185.1  C-terminal-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A1L8HT10, A0A974I2R3
      Conserved Domains (1) summary
      cd05299
      Location:29 → 347
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    4. XM_041586936.1 → XP_041442870.1  C-terminal-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A1L8HT10, A0A974I2R3
      Related
      ENSXLAP00005061267.1, ENSXLAT00005062719.1
      Conserved Domains (1) summary
      cd05299
      Location:29 → 347
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    5. XM_041587067.1 → XP_041443001.1  C-terminal-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8J1MNJ3
      Conserved Domains (1) summary
      cd05299
      Location:67 → 385
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9YHU0.1 GenPept UniProtKB/Swiss-Prot:Q9YHU0

    Gene LinkOut

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