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    Stk25 serine/threonine kinase 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 373542, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Stk25provided by RGD
    Official Full Name
    serine/threonine kinase 25provided by RGD
    Primary source
    RGD:727809
    See related
    EnsemblRapid:ENSRNOG00000018181 AllianceGenome:RGD:727809
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including establishment of Golgi localization; intrinsic apoptotic signaling pathway in response to hydrogen peroxide; and positive regulation of stress-activated MAPK cascade. Predicted to act upstream of or within several processes, including Golgi localization; positive regulation of axonogenesis; and protein phosphorylation. Located in Golgi membrane. Orthologous to human STK25 (serine/threonine kinase 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 417.4), Lung (RPKM 316.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stk25 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101609218..101621458, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (94161834..94174095, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100767578..100779715, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene septin 2 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 2 Neighboring gene 5S ribosomal RNA Neighboring gene BCL2 family apoptosis regulator BOK Neighboring gene THAP domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle. Nerstedt A, et al. Diabetologia, 2012 Jun. PMID 22391949
    2. Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. Pombo CM, et al. EMBO J, 1996 Sep 2. PMID 8887545, Free PMC Article
    3. PDCD10 interacts with STK25 to accelerate cell apoptosis under oxidative stress. Zhang H, et al. Front Biosci (Landmark Ed), 2012 Jun 1. PMID 22652780
    4. Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Zhou J, et al. Mol Cell Biol, 2009 Aug. PMID 19451227, Free PMC Article
    5. YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. Preisinger C, et al. J Cell Biol, 2004 Mar 29. PMID 15037601, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study indicates a possible role for STK25 in the regulation of glucose and lipid metabolism in L6 myoblasts.
      Title: Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94619

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi reassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of Golgi localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 25
    Names
    serine/threonine kinase 25 (STE20 homolog, yeast)
    NP_908938.1
    XP_038939953.1
    XP_038939955.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_184049.1 → NP_908938.1  serine/threonine-protein kinase 25

      See identical proteins and their annotated locations for NP_908938.1

      Status: PROVISIONAL

      Source sequence(s)
      AY346152
      UniProtKB/TrEMBL
      A0A8I5ZQ80, F7ERC6, Q6V9V9
      Related
      ENSRNOP00000024487.4, ENSRNOT00000024487.6
      Conserved Domains (1) summary
      cd06642
      Location:15 → 291
      STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      101609218..101621458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084025.2 → XP_038939953.1  serine/threonine-protein kinase 25 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 197
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039084027.2 → XP_038939955.1  serine/threonine-protein kinase 25 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:15 → 257
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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