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    cora coracle [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37205, updated on 17-Dec-2024

    Summary

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    Official Symbol
    coraprovided by FlyBase
    Official Full Name
    coracleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010434
    Locus tag
    Dmel_CG11949
    See related
    AllianceGenome:FB:FBgn0010434
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11949; cor; Cor; COR; Cora; Coracle; D4.1; Dmel\CG11949; l(2)k08713; mdcds_14526
    Summary
    Predicted to enable actin binding activity and structural molecule activity. Involved in several processes, including adult somatic muscle development; cell adhesion involved in heart morphogenesis; and neurogenesis. Located in plasma membrane and smooth septate junction. Is expressed in several structures, including epidermis; epithelial cell; gut section; imaginal disc; and internal sense organ. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 11; esophagus squamous cell carcinoma; and hereditary elliptocytosis. Orthologous to several human genes including EPB41 (erythrocyte membrane protein band 4.1) and EPB41L1 (erythrocyte membrane protein band 4.1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cora in Genome Data Viewer
    Location:
    56C4-56C4; 2-88 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19229063..19243751)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15116568..15131256)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene happyhour Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene windbeutel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster Rac2 is necessary for a proper cellular immune response. Williams MJ, et al. Genes Cells, 2005 Aug. PMID 16098145
    2. Phosphatidylinositol-4,5 bisphosphate (PIP(2)) inhibits apo-calmodulin binding to protein 4.1. Nunomura W, et al. Biochem Biophys Res Commun, 2014 Apr 4. PMID 24607279
    3. The protein 4.1, ezrin, radixin, moesin (FERM) domain of Drosophila Coracle, a cytoplasmic component of the septate junction, provides functions essential for embryonic development and imaginal cell proliferation. Ward RE 4th, et al. Genetics, 2001 Sep. PMID 11560899, Free PMC Article
    4. Pictures in cell biology Rho-family proteins control polarized cytoskeletal rearrangements during wing hair formation in Drosophila. . Trends Cell Biol, 1997 Nov. PMID 17709002
    5. Functional studies of the protein 4.1 family of junctional proteins in Drosophila. Fehon RG, et al. Soc Gen Physiol Ser, 1997. PMID 9210227

    See all (351) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of epithelial integrity and organ growth by Tctp and Coracle in Drosophila.
      Title: Regulation of epithelial integrity and organ growth by Tctp and Coracle in Drosophila.
    2. Select Septate Junction Proteins Direct ROS-Mediated Paracrine Regulation of Drosophila Cardiac Function.
      Title: Select Septate Junction Proteins Direct ROS-Mediated Paracrine Regulation of Drosophila Cardiac Function.
    3. Drosophila FERM proteins Yurt (Yrt) and Coracle (Cora) and the membrane proteins Neurexin IV (Nrx-IV) and Na(+),K(+)-ATPase are a new group of functionally cooperating epithelial polarity proteins
      Title: Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins.
    4. Coracle interacts with the C terminus of GluRIIA but not GluRIIB. A-type glutamate receptors are anchored to the actin cytoskeleton via coracle.
      Title: The 4.1 protein coracle mediates subunit-selective anchoring of Drosophila glutamate receptors to the postsynaptic actin cytoskeleton.
    5. The apical polarization of Gli and Cora functions to stabilize and align prehairs relative to anterior-posterior cell boundaries during pupal wing development.
      Title: Transient apical polarization of Gliotactin and Coracle is required for parallel alignment of wing hairs in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adult somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion involved in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell junction organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of glial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of imaginal disc-derived wing hair orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in smooth septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coracle
    Names
    CG11949-PA
    CG11949-PB
    CG11949-PC
    CG11949-PE
    CG11949-PF
    CG11949-PG
    D4.1-Coracle
    cora-PA
    cora-PB
    cora-PC
    cora-PE
    cora-PF
    cora-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19229063..19243751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166336.2 → NP_725864.1  coracle, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725864.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V8R9
      Related
      FBpp0085694
      Conserved Domains (6) summary
      smart00295
      Location:34 → 224
      B41; Band 4.1 homologues
      cd13184
      Location:219 → 312
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:116 → 224
      FERM_M; FERM central domain
      pfam05902
      Location:617 → 703
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:323 → 363
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 98
      FERM_N; FERM N-terminal domain

    2. NM_166337.2 → NP_725865.1  coracle, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725865.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V8R9
      Related
      FBpp0085696
      Conserved Domains (6) summary
      smart00295
      Location:34 → 224
      B41; Band 4.1 homologues
      cd13184
      Location:219 → 312
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:116 → 224
      FERM_M; FERM central domain
      pfam05902
      Location:803 → 889
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:323 → 363
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 98
      FERM_N; FERM N-terminal domain

    3. NM_001299678.1 → NP_001286607.1  coracle, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFX4
      Conserved Domains (7) summary
      smart00295
      Location:34 → 224
      B41; Band 4.1 homologues
      cd13184
      Location:219 → 312
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:116 → 224
      FERM_M; FERM central domain
      pfam05902
      Location:1514 → 1600
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:323 → 363
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 98
      FERM_N; FERM N-terminal domain
      pfam13360
      Location:839 → 982
      PQQ_2; PQQ-like domain

    4. NM_079067.4 → NP_523791.2  coracle, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523791.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZBI0, Q1WWD0, Q24440, Q24441, Q24442, Q9V8R8, Q9V8R9, Q9V8S0
      Related
      FBpp0085697
      Conserved Domains (7) summary
      smart00295
      Location:34 → 224
      B41; Band 4.1 homologues
      cd13184
      Location:219 → 312
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:116 → 224
      FERM_M; FERM central domain
      pfam05902
      Location:1612 → 1698
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:323 → 363
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 98
      FERM_N; FERM N-terminal domain
      pfam13360
      Location:829 → 972
      PQQ_2; PQQ-like domain

    5. NM_001299679.1 → NP_001286608.1  coracle, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG23
      Conserved Domains (7) summary
      smart00295
      Location:34 → 224
      B41; Band 4.1 homologues
      cd13184
      Location:219 → 312
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:116 → 224
      FERM_M; FERM central domain
      pfam05902
      Location:1610 → 1696
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:323 → 363
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 98
      FERM_N; FERM N-terminal domain
      pfam13360
      Location:829 → 972
      PQQ_2; PQQ-like domain

    6. NM_166338.3 → NP_725866.1  coracle, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8A7
      Related
      FBpp0290494
      Conserved Domains (6) summary
      smart00295
      Location:34 → 224
      B41; Band 4.1 homologues
      cd13184
      Location:219 → 312
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:116 → 224
      FERM_M; FERM central domain
      pfam05902
      Location:613 → 699
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:323 → 363
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 98
      FERM_N; FERM N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFX4 A0A0B4LFX4
    A0A0B4LG23 A0A0B4LG23
    Q9V8R9.1 Q9V8R9

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