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    Rgk2 Rad, Gem/Kir family member 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37132, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rgk2provided by FlyBase
    Official Full Name
    Rad, Gem/Kir family member 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0085419
    Locus tag
    Dmel_CG34390
    See related
    AllianceGenome:FB:FBgn0085419
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15069; CG30119; CG34390; Dmel\CG34390; RGK2
    Old locus tag
    CG15069; CG30119; Dmel_CG15069; Dmel_CG30119
    Summary
    Enables calcium channel regulator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human REM1 (RRAD and GEM like GTPase 1); REM2 (RRAD and GEM like GTPase 2); and RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rgk2 in Genome Data Viewer
    Location:
    55D3-55D3; 2-86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18539585..18548969)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14427090..14436474)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphoenolpyruvate carboxykinase 2 Neighboring gene long non-coding RNA:CR46271 Neighboring gene uncharacterized protein Neighboring gene Phosphoenolpyruvate carboxykinase 1 Neighboring gene Guanine nucleotide exchange factor in mesoderm Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split. Puhl HL 3rd, et al. PLoS One, 2014. PMID 24992013, Free PMC Article
    2. Straightjacket/α2δ3 deregulation is associated with cardiac conduction defects in myotonic dystrophy type 1. Auxerre-Plantié E, et al. Elife, 2019 Dec 12. PMID 31829940, Free PMC Article
    3. Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation. Mattila J, et al. Sci Adv, 2024 Feb 9. PMID 38335286, Free PMC Article
    4. Evolutionary expansion of the Ras switch regulatory module in eukaryotes. Díez D, et al. Nucleic Acids Res, 2011 Jul. PMID 21447561, Free PMC Article
    5. Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression. Apidianakis Y, et al. Proc Natl Acad Sci U S A, 2005 Feb 15. PMID 15695583, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in small GTPase-mediated signal transduction ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rad, Gem/Kir family member 2
    Names
    CG34390-PA
    CG34390-PC
    Rgk2-PA
    Rgk2-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18539585..18548969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137498.3 → NP_611342.1  Rad, Gem/Kir family member 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611342.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN22
      Related
      FBpp0111545
      Conserved Domains (2) summary
      smart00010
      Location:527 → 692
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04148
      Location:527 → 740
      RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

    2. NM_001299648.1 → NP_001286577.1  Rad, Gem/Kir family member 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286577.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFV4
      Conserved Domains (2) summary
      smart00010
      Location:527 → 694
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04148
      Location:527 → 742
      RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFV4 A0A0B4LFV4
    Q6NN22 Q6NN22

    Gene LinkOut

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