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    CG8249 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36742, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8249provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034045
    Locus tag
    Dmel_CG8249
    See related
    AllianceGenome:FB:FBgn0034045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8249
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including adult head; anal pad primordium; dorsal epidermis primordium; embryonic anal pad; and gut section. Orthologous to human SLC2A6 (solute carrier family 2 member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8249 in Genome Data Viewer
    Location:
    52C8-52C8; 2-75 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15842760..15847362, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11730265..11734867, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene tungus Neighboring gene uncharacterized protein Neighboring gene Pox neuro Neighboring gene cGAS-like receptor 1 Neighboring gene Glycerophosphate oxidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Pox neuro gene: control of male courtship behavior and fertility as revealed by a complete dissection of all enhancers. Boll W, et al. Development, 2002 Dec. PMID 12421707
    2. Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Mattila J, et al. Cell Rep, 2015 Oct 13. PMID 26440885
    3. Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition. Zenk F, et al. Science, 2017 Jul 14. PMID 28706074
    4. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Bellen HJ, et al. Genetics, 2004 Jun. PMID 15238527, Free PMC Article
    5. The Drosophila blood-brain barrier: development and function of a glial endothelium. Limmer S, et al. Front Neurosci, 2014. PMID 25452710, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sugar transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8249-PA
    CG8249-PB
    CG8249-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15842760..15847362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259421.2 → NP_001246350.1  uncharacterized protein Dmel_CG8249, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246350.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA52
      Conserved Domains (2) summary
      cd06174
      Location:49 → 479
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:60 → 496
      Sugar_tr; Sugar (and other) transporter

    2. NM_137216.4 → NP_611060.2  uncharacterized protein Dmel_CG8249, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611060.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA52
      Related
      FBpp0086445
      Conserved Domains (2) summary
      cd06174
      Location:49 → 479
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:60 → 496
      Sugar_tr; Sugar (and other) transporter

    3. NM_001259420.2 → NP_001246349.1  uncharacterized protein Dmel_CG8249, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246349.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA52
      Conserved Domains (2) summary
      cd06174
      Location:49 → 479
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:60 → 496
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZA52 A1ZA52
    Q8SZ00 Q8SZ00

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