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    Foxb1 forkhead box B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Foxb1provided by RGD
    Official Full Name
    forkhead box B1provided by RGD
    Primary source
    RGD:1305217
    See related
    EnsemblRapid:ENSRNOG00000089953 AllianceGenome:RGD:1305217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including mammary gland development; nervous system development; and visual learning. Predicted to be located in nucleus. Orthologous to human FOXB1 (forkhead box B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 6.7) and Brain (RPKM 2.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Foxb1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (79288161..79290781, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (70407221..70409841, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (75992751..75995371, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693133 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC120094195 Neighboring gene uncharacterized LOC108351739 Neighboring gene small ribosomal subunit protein eS10-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genetic ablation of the mammillary bodies in the Foxb1 mutant mouse leads to selective deficit of spatial working memory. Radyushkin K, et al. Eur J Neurosci, 2005 Jan. PMID 15654859
    2. The winged helix gene, Foxb1, controls development of mammary glands and regions of the CNS that regulate the milk-ejection reflex. Kloetzli JM, et al. Genesis, 2001 Feb. PMID 11170346
    3. Foxb1-driven Cre expression in somites and the neuroepithelium of diencephalon, brainstem, and spinal cord. Zhao T, et al. Genesis, 2007 Dec. PMID 18064677
    4. Winged helix transcription factor Foxb1 is essential for access of mammillothalamic axons to the thalamus. Alvarez-Bolado G, et al. Development, 2000 Mar. PMID 10662642
    5. Genetic mapping of Foxb1-cell lineage shows migration from caudal diencephalon to telencephalon and lateral hypothalamus. Zhao T, et al. Eur J Neurosci, 2008 Nov. PMID 19046377, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109378

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon target recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration in diencephalon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation involved in mammary gland alveolus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in floor plate development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hypothalamus cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inferior colliculus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lactation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mammary gland lobule development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mammillary body development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mammillothalamic axonal tract development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in midbrain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spinal cord development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telencephalon cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thalamus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urogenital system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box protein B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013248.2 → NP_001013266.2  forkhead box protein B1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KEV8
      Related
      ENSRNOP00000106069.1, ENSRNOT00000128635.1
      Conserved Domains (1) summary
      cd20043
      Location:1 → 110
      FH_FOXB2; Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      79288161..79290781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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