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    Spt-I Serine palmitoyltransferase subunit I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36448, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spt-Iprovided by FlyBase
    Official Full Name
    Serine palmitoyltransferase subunit Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086532
    Locus tag
    Dmel_CG4016
    See related
    AllianceGenome:FB:FBgn0086532
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4016; Dmel\CG4016; dSpt1; l(2)49Fb; l(2)SH1626; l(2)SH2 1626; lcb1; SPT; SPT-I; Spt1; SPT1
    Summary
    Predicted to enable serine C-palmitoyltransferase activity. Involved in positive regulation of sphingolipid biosynthetic process. Predicted to be part of serine palmitoyltransferase complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult head; central brain primordium; embryonic brain; embryonic/larval midgut primordium; and gut section. Used to study hereditary sensory and autonomic neuropathy type 1; hereditary sensory and autonomic neuropathy type 1A; and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1A and juvenile amyotrophic lateral sclerosis type 27. Orthologous to human SPTLC1 (serine palmitoyltransferase long chain base subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spt-I in Genome Data Viewer
    Location:
    49F4-49F4; 2-68 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13168498..13170744)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9056003..9058249)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Neurospecific receptor kinase Neighboring gene uncharacterized protein Neighboring gene Glial Lazarillo Neighboring gene antisense RNA:CR45142 Neighboring gene 1,4-Alpha-Glucan Branching Enzyme Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila. Sanchez D, et al. Curr Biol, 2006 Apr 4. PMID 16581513
    2. Identification of dietary alanine toxicity and trafficking dysfunction in a Drosophila model of hereditary sensory and autonomic neuropathy type 1. Oswald MC, et al. Hum Mol Genet, 2015 Dec 15. PMID 26395456, Free PMC Article
    3. Wrapping axons in mammals and Drosophila: Different lipids, same principle. Murate M, et al. Biochimie, 2020 Nov. PMID 32800899
    4. Sphingolipid-dependent Dscam sorting regulates axon segregation. Goyal G, et al. Nat Commun, 2019 Feb 18. PMID 30778062, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons. Ghosh A, et al. PLoS Genet, 2013. PMID 24348263, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine C-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine C-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of serine palmitoyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    serine palmitoyltransferase subunit I
    Names
    CG4016-PA
    CG4016-PB
    CG4016-PC
    Spt-I-PA
    Spt-I-PB
    Spt-I-PC
    lethal (2) SH1626
    NP_610842.1
    NP_725255.1
    NP_725256.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13168498..13170744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165967.4 → NP_725255.1  serine palmitoyltransferase subunit I, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725255.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR46
      Related
      FBpp0086842
      Conserved Domains (2) summary
      COG0156
      Location:79 → 463
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
      cl18945
      Location:22 → 468
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    2. NM_165968.4 → NP_725256.1  serine palmitoyltransferase subunit I, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725256.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR46
      Related
      FBpp0086844
      Conserved Domains (2) summary
      COG0156
      Location:79 → 463
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
      cl18945
      Location:22 → 468
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    3. NM_136998.2 → NP_610842.1  serine palmitoyltransferase subunit I, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610842.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR46
      Related
      FBpp0086843
      Conserved Domains (2) summary
      COG0156
      Location:79 → 463
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
      cl18945
      Location:22 → 468
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NR46 Q6NR46

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