Kctd12 potassium channel tetramerization domain containing 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Kctd12provided by RGD
Full Name: potassium channel tetramerization domain containing 12provided by RGD
Primary source: RGD:1309421
See related: EnsemblRapid:ENSRNOG00000066973 AllianceGenome:RGD:1309421
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential; and identical protein binding activity. Predicted to be involved in protein homooligomerization; regulation of postsynaptic membrane potential; and regulation of presynaptic membrane potential. Predicted to act upstream of or within regulation of G protein-coupled receptor signaling pathway. Is active in postsynaptic membrane and presynaptic membrane. Orthologous to human KCTD12 (potassium channel tetramerization domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 15q21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (86214786..86220725, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (79800078..79806017, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (87384632..87390627, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study highlights that GABABRs differentially control cholecystokinin-expressing interneuron subtypes, and the kinetics and desensitization of GABABR-mediated currents are modulated by KCTD12 proteins
Title: KCTD12 Auxiliary Proteins Modulate Kinetics of GABAB Receptor-Mediated Inhibition in Cholecystokinin-Containing Interneurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI408351 (e-PCR)
- UniSTS:250139

RH141929 (e-PCR)
- UniSTS:223920

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BTB/POZ domain-containing protein KCTD12

Names: potassium channel tetramerisation domain containing 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399515.1 → NP_001386444.1 BTB/POZ domain-containing protein KCTD12

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A0A8I5Y7I2, A6HU83

Related

ENSRNOP00000077409.2, ENSRNOT00000110749.2

Conserved Domains (2) summary

cd18397
Location:32 → 131

BTB_POZ_KCTD12_Pfetin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12)

cd22217
Location:208 → 327

H1_KCTD12; H1 domain found in potassium channel tetramerization domain-containing protein 12