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    Hira histone cell cycle regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363849, updated on 9-Dec-2024

    Summary

    Symbol
    Hiraprovided by RGD
    Full Name
    histone cell cycle regulatorprovided by RGD
    Primary source
    RGD:1584950
    See related
    EnsemblRapid:ENSRNOG00000045770 AllianceGenome:RGD:1584950
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and histone binding activity. Predicted to contribute to nucleosome binding activity. Predicted to be involved in nucleosome assembly. Predicted to act upstream of or within gastrulation; muscle cell differentiation; and osteoblast differentiation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of HIR complex. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 58.7), Thymus (RPKM 53.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hira in Genome Data Viewer
    Location:
    11q23
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (95528831..95637565, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82024469..82133212, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86168196..86276430, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda constant 1 Neighboring gene uncharacterized LOC134480931 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene mitochondrial ribosomal protein L40 Neighboring gene similar to human chromosome 22 open reading frame 39

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within gastrulation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of HIR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein HIRA
    Names
    HIR histone cell cycle regulation defective homolog A
    histone cell cycle regulation defective homolog A
    protein HIRA-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135760.1NP_001129232.1  protein HIRA

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      M0R4R2
      Related
      ENSRNOP00000064357.1, ENSRNOT00000075164.3
      Conserved Domains (5) summary
      COG2319
      Location:7372
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:7352
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam07569
      Location:761952
      Hira; TUP1-like enhancer of split
      pfam09453
      Location:448469
      HIRA_B; HIRA B motif
      sd00039
      Location:1661
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      95528831..95637565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270679.1XP_063126749.1  protein HIRA isoform X2

      Related
      ENSRNOP00000098904.1, ENSRNOT00000121679.1
    2. XM_063270678.1XP_063126748.1  protein HIRA isoform X1

      UniProtKB/TrEMBL
      M0R756
      Related
      ENSRNOP00000109055.1, ENSRNOT00000129451.1
    3. XM_063270681.1XP_063126751.1  protein HIRA isoform X3

    4. XM_063270680.1XP_063126750.1  protein HIRA isoform X3

    5. XM_063270682.1XP_063126752.1  protein HIRA isoform X3

      Related
      ENSRNOP00000111605.1, ENSRNOT00000151189.1
    6. XM_063270683.1XP_063126753.1  protein HIRA isoform X4

    RNA

    1. XR_010055965.1 RNA Sequence