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    Cpr49Ac Cuticular protein 49Ac [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36348, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cpr49Acprovided by FlyBase
    Official Full Name
    Cuticular protein 49Acprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033725
    Locus tag
    Dmel_CG8502
    See related
    AllianceGenome:FB:FBgn0033725
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8502; Dmel\CG8502
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Located in extracellular region. Is expressed in several structures, including dorsal ectoderm anlage; embryonic foregut sensory structure; embryonic/larval fat body; eye disc posterior to the morphogenetic furrow; and imaginal disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cpr49Ac in Genome Data Viewer
    Location:
    49A1-49A2; 2-67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12386666..12390057)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8274171..8277562)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 49Ad Neighboring gene Odorant receptor 49a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A single-cell atlas of the developing Drosophila ovary identifies follicle stem cell progenitors. Slaidina M, et al. Genes Dev, 2020 Feb 1. PMID 31919193, Free PMC Article
    2. Drosophila P elements preferentially transpose to replication origins. Spradling AC, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21896744, Free PMC Article
    3. Mud Loss Restricts Yki-Dependent Hyperplasia in Drosophila Epithelia. Parra AS, et al. J Dev Biol, 2020 Dec 13. PMID 33322177, Free PMC Article
    4. Proteomic analysis of the Drosophila larval hemolymph clot. Karlsson C, et al. J Biol Chem, 2004 Dec 10. PMID 15466469
    5. SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system. Weake VM, et al. EMBO J, 2008 Jan 23. PMID 18188155, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chitin-based larval cuticle ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chitin-based extracellular matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 

    General protein information

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    Preferred Names
    cuticular protein 49Ac
    Names
    CG8502-PA
    CG8502-PC
    CG8502-PD
    CG8502-PE
    CG8502-PF
    CG8502-PG
    Cpr49Ac-PA
    Cpr49Ac-PC
    Cpr49Ac-PD
    Cpr49Ac-PE
    Cpr49Ac-PF
    Cpr49Ac-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12386666..12390057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299417.1 → NP_001286346.1  cuticular protein 49Ac, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286346.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG85
      Conserved Domains (1) summary
      pfam00379
      Location:166 → 217
      Chitin_bind_4; Insect cuticle protein

    2. NM_165892.4 → NP_725150.2  cuticular protein 49Ac, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725150.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JR69
      Related
      FBpp0087027
      Conserved Domains (1) summary
      pfam00379
      Location:175 → 226
      Chitin_bind_4; Insect cuticle protein

    3. NM_001299416.1 → NP_001286345.1  cuticular protein 49Ac, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286345.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG85
      Conserved Domains (1) summary
      pfam00379
      Location:166 → 217
      Chitin_bind_4; Insect cuticle protein

    4. NM_001169656.2 → NP_001163127.1  cuticular protein 49Ac, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163127.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH44

    5. NM_136928.5 → NP_610772.3  cuticular protein 49Ac, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610772.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960H8, Q9I7F5
      Related
      FBpp0087028
      Conserved Domains (1) summary
      pfam00379
      Location:145 → 196
      Chitin_bind_4; Insect cuticle protein

    6. NM_001299415.1 → NP_001286344.1  cuticular protein 49Ac, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286344.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF74
      Conserved Domains (1) summary
      pfam00379
      Location:136 → 187
      Chitin_bind_4; Insect cuticle protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF74 A0A0B4LF74
    A0A0B4LG85 A0A0B4LG85
    E1JH44 E1JH44
    Q7JR69 Q7JR69
    Q960H8 Q960H8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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