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    Crtap cartilage associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363158, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crtapprovided by RGD
    Official Full Name
    cartilage associated proteinprovided by RGD
    Primary source
    RGD:1565180
    See related
    EnsemblRapid:ENSRNOG00000009878 AllianceGenome:RGD:1565180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crtapl1; RGD1565180
    Summary
    Predicted to contribute to collagen binding activity. Predicted to be involved in several processes, including collagen fibril organization; negative regulation of post-translational protein modification; and protein stabilization. Predicted to act upstream of or within peptidyl-proline hydroxylation to 3-hydroxy-L-proline. Predicted to be located in extracellular space. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 7. Orthologous to human CRTAP (cartilage associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 171.1), Lung (RPKM 89.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Crtap in Genome Data Viewer
    Location:
    8q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (122926117..122945843, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (114047929..114067636, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (122394451..122402198, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene sushi domain containing 5 Neighboring gene uncharacterized LOC134480241 Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein with metallophosphoesterase domain Neighboring gene galactosidase, beta 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in collagen fibril organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-proline hydroxylation to 3-hydroxy-L-proline ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cartilage-associated protein
    Names
    cartilage associated protein-like 1
    cartilage-associated protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108785.3NP_001102255.1  cartilage-associated protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_001102255.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I3N4, M0R3U4
    2. NM_001401203.1NP_001388132.1  cartilage-associated protein isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A096MK61, A6I3N2
      Related
      ENSRNOP00000068391.1, ENSRNOT00000076548.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      122926117..122945843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)