otk off-track [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: otkprovided by FlyBase
Official Full Name: off-trackprovided by FlyBase
Primary source: FLYBASE:FBgn0004839
Locus tag: Dmel_CG8967
See related: AllianceGenome:FB:FBgn0004839
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO2004063362.81; CG8967; CT25769; Dmel\CG8967; Dtkr; DTKR; dTrk; Dtrk; DTrk; IGGtyk; OFT/TRK; Otk; OTK; Tk48D; Trk48D
Summary: Enables several functions, including Wnt-protein binding activity; protein dimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including axon guidance; genitalia morphogenesis; and negative regulation of canonical Wnt signaling pathway. Located in axon and plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval midgut primordium; epithelium; gut section; and symmetrical commissure. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 48D6-48D7; 2-65 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12001473..12019846, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7888978..7907351, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility.
Title: Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility.
Overexpression of Otk causes female sterility due to malformation of the oviduct, indicating that Otk and Otk2 are specifically involved in the sexually dimorphic development of the genital tract.
Title: The PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertility.
In Drosophila, Otk interacts with Wnt4 and opposes canonical Wnt signalling in embryonic patterning.
Title: PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling.
Otk is a receptor or a component of a receptor complex that recognizes a target-derived signal for R cell 1-R cell 6 axons to innervate the lamina layer
Title: The receptor tyrosine kinase Off-track is required for layer-specific neuronal connectivity in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell adhesion molecule binding	IDA Inferred from Direct Assay more info	PubMed
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor binding	TAS Traceable Author Statement more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in imaginal disc-derived female genitalia morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in internal genitalia morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: off-track

Names: CG8967-PA; CG8967-PB; Off-track; off track; offtrack; otk-PA; otk-PB; tyrosine kinase at 48D

NP_001286325.1

EC 2.7.10.1

NP_523705.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

12001473..12019846 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078981.3 → NP_523705.2 off-track, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523705.2

Status: REVIEWED

UniProtKB/Swiss-Prot

C4IXZ4, Q24327, Q6AWJ9

Related

FBpp0087135

Conserved Domains (6) summary

cd05046
Location:686 → 1026

PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4

cd00096
Location:395 → 460

Ig; Immunoglobulin domain

smart00408
Location:484 → 549

IGc2; Immunoglobulin C-2 Type

smart00221
Location:692 → 1020

STYKc; Protein kinase; unclassified specificity

pfam07679
Location:468 → 559

I-set; Immunoglobulin I-set domain

cl11960
Location:31 → 115

Ig; Immunoglobulin domain
NM_001299396.1 → NP_001286325.1 off-track, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286325.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LF75

Conserved Domains (6) summary

cd00096
Location:395 → 460

Ig; Immunoglobulin domain

smart00408
Location:484 → 549

IGc2; Immunoglobulin C-2 Type

smart00221
Location:692 → 1005

STYKc; Protein kinase; unclassified specificity

pfam07679
Location:468 → 559

I-set; Immunoglobulin I-set domain

cl11960
Location:31 → 115

Ig; Immunoglobulin domain

cl21453
Location:686 → 1003

PKc_like; Protein Kinases, catalytic domain