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    Lclat1 lysocardiolipin acyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362702, updated on 3-Dec-2024

    Summary

    Official Symbol
    Lclat1provided by RGD
    Official Full Name
    lysocardiolipin acyltransferase 1provided by RGD
    Primary source
    RGD:1565906
    See related
    EnsemblRapid:ENSRNOG00000034026 AllianceGenome:RGD:1565906
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lycat; RGD1565906
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Predicted to be located in cytosol. Predicted to be active in endoplasmic reticulum. Orthologous to human LCLAT1 (lysocardiolipin acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 55.5), Lung (RPKM 24.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lclat1 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (27980749..28125076, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (22228933..22373246, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (24377398..24515412)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479330 Neighboring gene uncharacterized LOC102547438 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC100912066 Neighboring gene uncharacterized LOC108351184

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lysocardiolipin acyltransferase 1
    XP_038969005.1
    XP_038969006.1
    XP_038969007.1
    XP_038969009.1
    XP_038969010.1
    XP_038969011.1
    XP_063118810.1
    XP_063118811.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431929.1NP_001418858.1  lysocardiolipin acyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFV0, A6HA05, D3ZFF4
    2. NM_001431930.1NP_001418859.1  lysocardiolipin acyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFV0, A6HA05, D3ZFF4
    3. NM_001431931.1NP_001418860.1  lysocardiolipin acyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFV0, A6HA05, D3ZFF4
    4. NM_001431932.1NP_001418861.1  lysocardiolipin acyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFV0, A6HA05, D3ZFF4
    5. NM_001431933.1NP_001418862.1  lysocardiolipin acyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFV0, A6HA05, D3ZFF4
    6. NM_001431934.1NP_001418863.1  lysocardiolipin acyltransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFV0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      27980749..28125076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113081.2XP_038969009.1  lysocardiolipin acyltransferase 1 isoform X1

      Related
      ENSRNOP00000112795.1, ENSRNOT00000160802.1
      Conserved Domains (2) summary
      cd07990
      Location:55248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:233306
      Acyltransf_C; Acyltransferase C-terminus
    2. XM_039113082.2XP_038969010.1  lysocardiolipin acyltransferase 1 isoform X2

      Conserved Domains (1) summary
      cd07990
      Location:55209
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    3. XM_039113078.2XP_038969006.1  lysocardiolipin acyltransferase 1 isoform X1

      Conserved Domains (2) summary
      cd07990
      Location:55248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:233306
      Acyltransf_C; Acyltransferase C-terminus
    4. XM_039113079.2XP_038969007.1  lysocardiolipin acyltransferase 1 isoform X1

      Related
      ENSRNOP00000112548.1, ENSRNOT00000166282.1
      Conserved Domains (2) summary
      cd07990
      Location:55248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:233306
      Acyltransf_C; Acyltransferase C-terminus
    5. XM_063262741.1XP_063118811.1  lysocardiolipin acyltransferase 1 isoform X1

      Related
      ENSRNOP00000050960.3, ENSRNOT00000043641.7
    6. XM_063262740.1XP_063118810.1  lysocardiolipin acyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AFV0, A6HA05, D3ZFF4
    7. XM_039113083.2XP_038969011.1  lysocardiolipin acyltransferase 1 isoform X3

      Conserved Domains (2) summary
      cd07990
      Location:1188
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:173246
      Acyltransf_C; Acyltransferase C-terminus
    8. XM_039113077.2XP_038969005.1  lysocardiolipin acyltransferase 1 isoform X1

      Conserved Domains (2) summary
      cd07990
      Location:55248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:233306
      Acyltransf_C; Acyltransferase C-terminus