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    Ppp1r21 protein phosphatase 1, regulatory subunit 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362697, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp1r21provided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 21provided by RGD
    Primary source
    RGD:1565310
    See related
    EnsemblRapid:ENSRNOG00000016528 AllianceGenome:RGD:1565310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565310
    Summary
    Predicted to enable RNA binding activity. Predicted to be active in early endosome. Orthologous to human PPP1R21 (protein phosphatase 1 regulatory subunit 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 105.8), Thymus (RPKM 95.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp1r21 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (11655059..11724219, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (5901518..5970684, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (12253788..12323427)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene stonin 1 Neighboring gene uncharacterized LOC134479304 Neighboring gene ubiquitin-conjugating enzyme E2S, pseudogene 2 Neighboring gene uncharacterized LOC102546644 Neighboring gene forkhead box N2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biallelic loss of function variants in PPP1R21 cause a neurodevelopmental syndrome with impaired endocytic function. Rehman AU, et al. Hum Mutat, 2019 Mar. PMID 30520571, Free PMC Article
    2. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Bithell A, et al. Brain Res Dev Brain Res, 2003 Dec 19. PMID 14643017
    3. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271305.1 → NP_001258234.1  protein phosphatase 1 regulatory subunit 21

      See identical proteins and their annotated locations for NP_001258234.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6B588, A6H9C0, F1LYZ8
      Related
      ENSRNOP00000058387.4, ENSRNOT00000061675.7
      Conserved Domains (2) summary
      pfam10205
      Location:11 → 111
      KLRAQ; Predicted coiled-coil domain-containing protein
      pfam10212
      Location:255 → 771
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      11655059..11724219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764482.4 → XP_008762704.1  protein phosphatase 1 regulatory subunit 21 isoform X1

      UniProtKB/TrEMBL
      A0A8I6B588
      Conserved Domains (2) summary
      pfam10205
      Location:1 → 65
      KLRAQ; Predicted coiled-coil domain-containing protein
      pfam10212
      Location:209 → 725
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein
    Nucleotide Protein Strain
    Heading Accession and Version

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