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    Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362361, updated on 27-Nov-2024

    Summary

    Official Symbol
    Hnrnpa2b1provided by RGD
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A2/B1provided by RGD
    Primary source
    RGD:1310403
    See related
    EnsemblRapid:ENSRNOG00000011175 AllianceGenome:RGD:1310403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    hnRNP; Hnrpa2; Hnrpa2b1
    Summary
    Enables DNA polymerase binding activity and nucleic acid binding activity. Involved in several processes, including chromosome organization; mRNA export from nucleus; and positive regulation of telomere maintenance via telomere lengthening. Located in several cellular components, including chromosome; neuronal ribonucleoprotein granule; and nuclear lumen. Is active in glutamatergic synapse; postsynaptic cytosol; and postsynaptic density. Used to study rheumatoid arthritis. Biomarker of hepatocellular carcinoma; pancreatic carcinoma; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 1081.1), Spleen (RPKM 825.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hnrnpa2b1 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (81867354..81875886, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (80534659..80545297, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (81237496..81241281, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102270 Neighboring gene NFE2 like bZIP transcription factor 3 Neighboring gene chromobox 3 Neighboring gene igE-binding protein-like Neighboring gene translocase of outer mitochondrial membrane 20 like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables G-rich strand telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables N6-methyladenosine-containing RNA reader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables N6-methyladenosine-containing RNA reader activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables N6-methyladenosine-containing RNA reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA CDS binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables miRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables molecular condensate scaffold activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pre-mRNA intronic binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables regulatory region RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables single-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables single-stranded telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G-quadruplex DNA unwinding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in RNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lung development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in miRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in miRNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligodendrocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of telomere maintenance via telomere lengthening IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in primary miRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in primary miRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to mineralocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in telomere capping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoproteins A2/B1
    Names
    heterogeneous nuclear ribonucleoprotein A2
    heterogeneous nuclear ribonucleoprotein B0a
    heterogeneous nuclear ribonucleoprotein B0b
    heterogeneous nuclear ribonucleoprotein B1
    hnRNP A2 / hnRNP B1
    hnRNP A2/B1
    nuclear ribonucleoprotein particle A2 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104613.2NP_001098083.2  heterogeneous nuclear ribonucleoproteins A2/B1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      A7VJC1, A7VJC2, A7VJC3, A7VJC4
      UniProtKB/TrEMBL
      F1LNF1
      Conserved Domains (3) summary
      pfam11627
      Location:302326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      81867354..81875886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286268.1XP_063142338.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

      Related
      ENSRNOP00000077328.2, ENSRNOT00000116353.2
    2. XM_063286267.1XP_063142337.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

    3. XM_039107793.2XP_038963721.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

      UniProtKB/Swiss-Prot
      A7VJC1, A7VJC2, A7VJC3, A7VJC4
      UniProtKB/TrEMBL
      A0A8I5Y7N4, A6K0N6
      Conserved Domains (3) summary
      pfam11627
      Location:290314
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    4. XM_063286263.1XP_063142333.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y7N4, A6K0N6
    5. XM_063286264.1XP_063142334.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y7N4, A6K0N6
    6. XM_039107795.2XP_038963723.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5YC50
      Conserved Domains (3) summary
      pfam11627
      Location:260286
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    7. XM_039107790.2XP_038963718.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

      UniProtKB/Swiss-Prot
      A7VJC1, A7VJC2, A7VJC3, A7VJC4
      UniProtKB/TrEMBL
      F1LNF1
      Conserved Domains (3) summary
      pfam11627
      Location:302326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    8. XM_039107791.2XP_038963719.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

      UniProtKB/Swiss-Prot
      A7VJC1, A7VJC2, A7VJC3, A7VJC4
      UniProtKB/TrEMBL
      F1LNF1
      Conserved Domains (3) summary
      pfam11627
      Location:302326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    9. XM_063286265.1XP_063142335.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

    10. XM_039107789.2XP_038963717.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

      UniProtKB/Swiss-Prot
      A7VJC1, A7VJC2, A7VJC3, A7VJC4
      UniProtKB/TrEMBL
      F1LNF1
      Related
      ENSRNOP00000015152.4, ENSRNOT00000015152.8
      Conserved Domains (3) summary
      pfam11627
      Location:302326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    11. XM_039107796.2XP_038963724.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5YC50
      Conserved Domains (3) summary
      pfam11627
      Location:248274
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    12. XM_039107792.2XP_038963720.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

      UniProtKB/Swiss-Prot
      A7VJC1, A7VJC2, A7VJC3, A7VJC4
      UniProtKB/TrEMBL
      A0A8I5Y7N4, A6K0N6
      Conserved Domains (3) summary
      pfam11627
      Location:290314
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    13. XM_039107794.2XP_038963722.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5YC50
      Conserved Domains (3) summary
      pfam11627
      Location:260286
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

    RNA

    1. XR_010065672.1 RNA Sequence

    2. XR_010065671.1 RNA Sequence

    3. XR_010065674.1 RNA Sequence

    4. XR_010065673.1 RNA Sequence

    5. XR_010065668.1 RNA Sequence

    6. XR_010065666.1 RNA Sequence

    7. XR_010065669.1 RNA Sequence

    8. XR_010065667.1 RNA Sequence

    9. XR_010065670.1 RNA Sequence

    10. XR_005503252.2 RNA Sequence

    11. XR_005503250.2 RNA Sequence

    12. XR_010065665.1 RNA Sequence

    13. XR_010065664.1 RNA Sequence