Rnf115 ring finger protein 115 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf115provided by RGD
Official Full Name: ring finger protein 115provided by RGD
Primary source: RGD:1305315
See related: EnsemblRapid:ENSRNOG00000000098 AllianceGenome:RGD:1305315
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zfp364
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of signal transduction; protein ubiquitination; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in cytosol. Predicted to be active in endoplasmic reticulum. Orthologous to human RNF115 (ring finger protein 115). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 288.2), Muscle (RPKM 215.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (186950959..187018673)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (184262087..184329839)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (198852392..198920000)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH133300 (e-PCR)
- UniSTS:216583

RH137670 (e-PCR)
- UniSTS:219757

BI284352 (e-PCR)
- UniSTS:244089

D2Got119 (e-PCR)
- UniSTS:115076

AU042696 (e-PCR)
- UniSTS:159158

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF115

Names: zinc finger protein 364

NP_001102030.2

EC 2.3.2.27

XP_038958628.1

EC 2.3.2.27

XP_038958630.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108560.2 → NP_001102030.2 E3 ubiquitin-protein ligase RNF115

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6K395, D3ZB96

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

186950959..187018673

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102700.2 → XP_038958628.1 E3 ubiquitin-protein ligase RNF115 isoform X1

Related

ENSRNOP00000000110.6, ENSRNOT00000000110.8

Conserved Domains (1) summary

cd16800
Location:306 → 352

RING-H2_RNF115; RING finger, H2 subclass, found in RING finger protein 115 (RNF115) and similar proteins
XM_039102702.2 → XP_038958630.1 E3 ubiquitin-protein ligase RNF115 isoform X2

Conserved Domains (1) summary

cd16800
Location:146 → 192

RING-H2_RNF115; RING finger, H2 subclass, found in RING finger protein 115 (RNF115) and similar proteins