U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ank3 ankyrin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361833, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ank3provided by RGD
    Official Full Name
    ankyrin 3provided by RGD
    Primary source
    RGD:620157
    See related
    EnsemblRapid:ENSRNOG00000053288 AllianceGenome:RGD:620157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ANK-3
    Summary
    Enables several functions, including cadherin binding activity; spectrin binding activity; and transmembrane transporter binding activity. Involved in several processes, including neuron development; positive regulation of cell communication; and regulation of monoatomic ion transport. Located in several cellular components, including main axon; myofibril; and spectrin-associated cytoskeleton. Is active in glutamatergic synapse and postsynapse. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 37; bipolar disorder; and schizophrenia. Orthologous to human ANK3 (ankyrin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 209.2), Brain (RPKM 178.2) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ank3 in Genome Data Viewer
    Location:
    20p11
    Exon count:
    57
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (18601307..19224790, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (18602267..19225831, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (19948767..20480628)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S26-like Neighboring gene myoregulin Neighboring gene coiled-coil domain containing 6 Neighboring gene uncharacterized LOC102553944 Neighboring gene small nucleolar RNA SNORD65 Neighboring gene uncharacterized LOC134483901 Neighboring gene uncharacterized LOC102554153 Neighboring gene uncharacterized LOC134483902 Neighboring gene uncharacterized LOC134483899 Neighboring gene uncharacterized LOC134483900 Neighboring gene uncharacterized LOC134483903 Neighboring gene uncharacterized LOC120099015 Neighboring gene dynein light chain Tctex-type 2B, pseudogene 1 Neighboring gene ST13, Hsp70 interacting protein, pseudogene 10 Neighboring gene ribosomal protein L29, pseudogene 2 Neighboring gene cyclin-dependent kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cadherin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cytoskeletal protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytoskeletal protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphorylation-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anterograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to magnesium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to magnesium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in clustering of voltage-gated sodium channels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment or maintenance of microtubule cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in magnesium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in maintenance of protein location in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maintenance of protein location in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of protein location in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in membrane assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of delayed rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuromuscular junction development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell communication by electrical coupling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of homotypic cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of membrane depolarization during cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of sodium ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of sodium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to axon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to axon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of modification of postsynaptic structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of modification of postsynaptic structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein targeting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon initial segment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon initial segment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in axon initial segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in costamere IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in costamere TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in node of Ranvier IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in node of Ranvier ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in paranode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spectrin-associated cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ankyrin-3
    Names
    ankyrin 3 (G)
    ankyrin 3, epithelial
    ankyrin 3, node of Ranvier (ankyrin G)
    ankyrin-G

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033984.1NP_001029156.1  ankyrin-3 isoform 2

      See identical proteins and their annotated locations for NP_001029156.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest variant and it encodes the longest protein (isoform 2). Isoform 2 is also known as '270 kDa ankyrin-G'.
      Source sequence(s)
      AF102552, AJ812023
      UniProtKB/Swiss-Prot
      O70511, Q574D7, Q574D8, Q574D9, Q574E0, Q574E2, Q8VDA0
      UniProtKB/TrEMBL
      A6JKS2
      Related
      ENSRNOP00000088491.1, ENSRNOT00000100191.2
      Conserved Domains (7) summary
      smart00218
      Location:9901094
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:23342417
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:78164
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:639692
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:757811
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:704735
      ANK; ANK repeat [structural motif]
    2. NM_031805.2NP_113993.1  ankyrin-3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has a different 5' UTR and multiple differences in the coding region but maintains the reading frame, compared to variant 2. This variant encodes isoform 1 which is shorter than isoform 2. Isoform 1 is also known as AnkG217.
      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      O70511
      Related
      ENSRNOP00000071942.2, ENSRNOT00000090273.3
      Conserved Domains (7) summary
      smart00218
      Location:9431047
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14241507
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:51176
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:61147
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:614667
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:732786
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:679710
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      18601307..19224790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279273.1XP_063135343.1  ankyrin-3 isoform X32

    2. XM_039098850.2XP_038954778.1  ankyrin-3 isoform X37

      Conserved Domains (7) summary
      smart00218
      Location:9761080
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14691552
      Death_ank3; Death domain of Ankyrin-3
      PHA03095
      Location:363651
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:690721
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:757809
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13021431
      UPA_2; UPA domain
      cl39094
      Location:545782
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_063279282.1XP_063135352.1  ankyrin-3 isoform X47

      Related
      ENSRNOP00000072993.2, ENSRNOT00000085985.3
    4. XM_063279281.1XP_063135351.1  ankyrin-3 isoform X46

    5. XM_063279269.1XP_063135339.1  ankyrin-3 isoform X26

    6. XM_063279258.1XP_063135328.1  ankyrin-3 isoform X11

      Related
      ENSRNOP00000112600.1, ENSRNOT00000152031.1
    7. XM_063279252.1XP_063135322.1  ankyrin-3 isoform X5

    8. XM_063279249.1XP_063135319.1  ankyrin-3 isoform X2

    9. XM_063279253.1XP_063135323.1  ankyrin-3 isoform X6

    10. XM_063279251.1XP_063135321.1  ankyrin-3 isoform X4

    11. XM_063279248.1XP_063135318.1  ankyrin-3 isoform X1

    12. XM_063279255.1XP_063135325.1  ankyrin-3 isoform X8

    13. XM_063279257.1XP_063135327.1  ankyrin-3 isoform X10

    14. XM_063279256.1XP_063135326.1  ankyrin-3 isoform X9

    15. XM_063279254.1XP_063135324.1  ankyrin-3 isoform X7

    16. XM_063279263.1XP_063135333.1  ankyrin-3 isoform X18

    17. XM_063279250.1XP_063135320.1  ankyrin-3 isoform X3

    18. XM_063279259.1XP_063135329.1  ankyrin-3 isoform X12

    19. XM_063279283.1XP_063135353.1  ankyrin-3 isoform X48

    20. XM_063279266.1XP_063135336.1  ankyrin-3 isoform X21

    21. XM_063279264.1XP_063135334.1  ankyrin-3 isoform X19

    22. XM_063279262.1XP_063135332.1  ankyrin-3 isoform X17

    23. XM_063279285.1XP_063135355.1  ankyrin-3 isoform X50

    24. XM_039098836.2XP_038954764.1  ankyrin-3 isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZUT6
      Conserved Domains (10) summary
      smart00218
      Location:9821086
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:40414124
      Death_ank3; Death domain of Ankyrin-3
      PTZ00449
      Location:20442316
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:369657
      PHA03095; ankyrin-like protein; Provisional
      pfam05109
      Location:14771879
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam11081
      Location:32293350
      DUF2890; Protein of unknown function (DUF2890)
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13081437
      UPA_2; UPA domain
      cl39094
      Location:551788
      Ank_2; Ankyrin repeats (3 copies)
    25. XM_063279261.1XP_063135331.1  ankyrin-3 isoform X16

    26. XM_063279284.1XP_063135354.1  ankyrin-3 isoform X49

    27. XM_063279260.1XP_063135330.1  ankyrin-3 isoform X13

    28. XM_063279265.1XP_063135335.1  ankyrin-3 isoform X20

    29. XM_063279267.1XP_063135337.1  ankyrin-3 isoform X23

      UniProtKB/TrEMBL
      A6JKS2
    30. XM_039098838.2XP_038954766.1  ankyrin-3 isoform X22

      UniProtKB/TrEMBL
      A0A8I6A9I9, A6JKS2
      Conserved Domains (9) summary
      smart00218
      Location:9901094
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:23342417
      Death_ank3; Death domain of Ankyrin-3
      PTZ00449
      Location:20452317
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:377665
      PHA03095; ankyrin-like protein; Provisional
      pfam05109
      Location:14721880
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:704735
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:771823
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13161445
      UPA_2; UPA domain
      cl39094
      Location:559796
      Ank_2; Ankyrin repeats (3 copies)
    31. XM_039098839.2XP_038954767.1  ankyrin-3 isoform X24

      Conserved Domains (7) summary
      smart00218
      Location:9821086
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14751558
      Death_ank3; Death domain of Ankyrin-3
      PHA03095
      Location:369657
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13081437
      UPA_2; UPA domain
      cl39094
      Location:551788
      Ank_2; Ankyrin repeats (3 copies)
    32. XM_063279268.1XP_063135338.1  ankyrin-3 isoform X25

    33. XM_063279271.1XP_063135341.1  ankyrin-3 isoform X29

    34. XM_063279270.1XP_063135340.1  ankyrin-3 isoform X27

    35. XM_039098842.2XP_038954770.1  ankyrin-3 isoform X28

      Related
      ENSRNOP00000095836.1, ENSRNOT00000116271.2
      Conserved Domains (7) summary
      smart00218
      Location:9821086
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14751558
      Death_ank3; Death domain of Ankyrin-3
      PHA03095
      Location:369657
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13081437
      UPA_2; UPA domain
      cl39094
      Location:551788
      Ank_2; Ankyrin repeats (3 copies)
    36. XM_063279272.1XP_063135342.1  ankyrin-3 isoform X31

    37. XM_039098844.2XP_038954772.1  ankyrin-3 isoform X30

      Conserved Domains (7) summary
      smart00218
      Location:9611065
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14541537
      Death_ank3; Death domain of Ankyrin-3
      PHA03095
      Location:369657
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12871416
      UPA_2; UPA domain
      cl39094
      Location:551788
      Ank_2; Ankyrin repeats (3 copies)
    38. XM_039098845.2XP_038954773.1  ankyrin-3 isoform X33

      Conserved Domains (7) summary
      smart00218
      Location:9611065
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14541537
      Death_ank3; Death domain of Ankyrin-3
      PHA03095
      Location:369657
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12871416
      UPA_2; UPA domain
      cl39094
      Location:551788
      Ank_2; Ankyrin repeats (3 copies)
    39. XM_063279275.1XP_063135345.1  ankyrin-3 isoform X36

    40. XM_063279274.1XP_063135344.1  ankyrin-3 isoform X34

    41. XM_063279278.1XP_063135348.1  ankyrin-3 isoform X41

    42. XM_039098849.2XP_038954777.1  ankyrin-3 isoform X35

      Conserved Domains (7) summary
      smart00218
      Location:9821086
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14751558
      Death_ank3; Death domain of Ankyrin-3
      PHA03095
      Location:369657
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13081437
      UPA_2; UPA domain
      cl39094
      Location:551788
      Ank_2; Ankyrin repeats (3 copies)
    43. XM_063279277.1XP_063135347.1  ankyrin-3 isoform X39

    44. XM_039098851.2XP_038954779.1  ankyrin-3 isoform X40

      Conserved Domains (7) summary
      smart00218
      Location:9611065
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14541537
      Death_ank3; Death domain of Ankyrin-3
      PHA03095
      Location:369657
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12871416
      UPA_2; UPA domain
      cl39094
      Location:551788
      Ank_2; Ankyrin repeats (3 copies)
    45. XM_063279279.1XP_063135349.1  ankyrin-3 isoform X42

      UniProtKB/TrEMBL
      Q574E1
    46. XM_039098852.2XP_038954780.1  ankyrin-3 isoform X43

      UniProtKB/TrEMBL
      A6JKS7, Q3T1J5
      Conserved Domains (3) summary
      smart00218
      Location:116220
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:609692
      Death_ank3; Death domain of Ankyrin-3
      pfam17809
      Location:442571
      UPA_2; UPA domain
    47. XM_063279280.1XP_063135350.1  ankyrin-3 isoform X45

      UniProtKB/TrEMBL
      Q3T1J5
    48. XM_039098853.2XP_038954781.1  ankyrin-3 isoform X44

      UniProtKB/TrEMBL
      A6JKS6, Q3T1J5
      Conserved Domains (3) summary
      smart00218
      Location:116220
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:609692
      Death_ank3; Death domain of Ankyrin-3
      pfam17809
      Location:442571
      UPA_2; UPA domain
    49. XM_039098834.2XP_038954762.1  ankyrin-3 isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZUT6
      Conserved Domains (10) summary
      smart00218
      Location:9821086
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:40414124
      Death_ank3; Death domain of Ankyrin-3
      PTZ00449
      Location:20442316
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:369657
      PHA03095; ankyrin-like protein; Provisional
      pfam05109
      Location:14771879
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam11081
      Location:32293350
      DUF2890; Protein of unknown function (DUF2890)
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13081437
      UPA_2; UPA domain
      cl39094
      Location:551788
      Ank_2; Ankyrin repeats (3 copies)
    50. XM_063279276.1XP_063135346.1  ankyrin-3 isoform X38