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    Relt RELT, TNF receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Reltprovided by RGD
    Official Full Name
    RELT, TNF receptorprovided by RGD
    Primary source
    RGD:1305381
    See related
    EnsemblRapid:ENSRNOG00000025075 AllianceGenome:RGD:1305381
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tnfrsf19l
    Summary
    Predicted to be involved in amelogenesis and apoptotic process. Predicted to be located in nucleoplasm. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 3C. Orthologous to human RELT (RELT TNF receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 34.4), Muscle (RPKM 27.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Relt in Genome Data Viewer
    Location:
    1q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164619059..164636707, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (155206976..155224609, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165884407..165902022, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RAB6A, member RAS oncogene family Neighboring gene pleckstrin homology domain containing B1 Neighboring gene family with sequence similarity 168, member A Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene microRNA 3102 Neighboring gene pyrimidinergic receptor P2Y6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in RELT cause autosomal recessive amelogenesis imperfecta. Kim JW, et al. Clin Genet, 2019 Mar. PMID 30506946, Free PMC Article
    2. The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation. Polek TC, et al. Biochem Biophys Res Commun, 2006 Apr 28. PMID 16530727
    3. RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1. Moua P, et al. Biochem Biophys Res Commun, 2017 Sep 9. PMID 28688764, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in amelogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amelogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 19L
    Names
    RELT tumor necrosis factor receptor
    tumor necrosis factor receptor superfamily, member 19-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108495.1 → NP_001101965.1  tumor necrosis factor receptor superfamily member 19L precursor

      See identical proteins and their annotated locations for NP_001101965.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A6I6R8, F1LVW5
      Related
      ENSRNOP00000036110.6, ENSRNOT00000038408.8
      Conserved Domains (2) summary
      cd13419
      Location:26 → 112
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:161 → 196
      RELT; tumor necrosis factor receptor superfamily member 19

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      164619059..164636707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082537.2 → XP_038938465.1  tumor necrosis factor receptor superfamily member 19L isoform X2

      UniProtKB/TrEMBL
      A6I6R8, F1LVW5
      Conserved Domains (2) summary
      cd13419
      Location:26 → 112
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:161 → 196
      RELT; tumor necrosis factor receptor superfamily member 19

    2. XM_006229777.5 → XP_006229839.1  tumor necrosis factor receptor superfamily member 19L isoform X2

      See identical proteins and their annotated locations for XP_006229839.1

      UniProtKB/TrEMBL
      A6I6R8, F1LVW5
      Conserved Domains (2) summary
      cd13419
      Location:26 → 112
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:161 → 196
      RELT; tumor necrosis factor receptor superfamily member 19

    3. XM_006229775.3 → XP_006229837.1  tumor necrosis factor receptor superfamily member 19L isoform X1

      Related
      ENSRNOP00000101803.1, ENSRNOT00000144857.1
      Conserved Domains (2) summary
      cd13419
      Location:73 → 159
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:208 → 243
      RELT; Tumour necrosis factor receptor superfamily member 19

    4. XM_039082543.2 → XP_038938471.1  tumor necrosis factor receptor superfamily member 19L isoform X2

      UniProtKB/TrEMBL
      A6I6R8, F1LVW5
      Conserved Domains (2) summary
      cd13419
      Location:26 → 112
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:161 → 196
      RELT; tumor necrosis factor receptor superfamily member 19

    5. XM_006229780.4 → XP_006229842.1  tumor necrosis factor receptor superfamily member 19L isoform X3

      Conserved Domains (2) summary
      cd13419
      Location:73 → 159
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:208 → 243
      RELT; Tumour necrosis factor receptor superfamily member 19
    Nucleotide Protein Strain
    Heading Accession and Version

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