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    Echdc1 ethylmalonyl-CoA decarboxylase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361465, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Echdc1provided by RGD
    Official Full Name
    ethylmalonyl-CoA decarboxylase 1provided by RGD
    Primary source
    RGD:1359654
    See related
    EnsemblRapid:ENSRNOG00000011622 AllianceGenome:RGD:1359654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MMCD
    Summary
    Predicted to enable carboxy-lyase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in cytosol. Orthologous to human ECHDC1 (ethylmalonyl-CoA decarboxylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 127.4), Adrenal (RPKM 90.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Echdc1 in Genome Data Viewer
    Location:
    1p11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (30304968..30355957, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (28476354..28507173, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (30874410..30921117, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 23 Neighboring gene ring finger protein 146 Neighboring gene liver enriched gene 1, pseudogene 1 Neighboring gene ADP-ribosylation factor 1, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading. Linster CL, et al. J Biol Chem, 2011 Dec 16. PMID 22016388, Free PMC Article
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93992

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxy-lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxy-lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyl/ethyl malonyl-CoA decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ethylmalonyl-CoA decarboxylase
    Names
    enoyl CoA hydratase domain containing 1
    enoyl Coenzyme A hydratase domain containing 1
    enoyl-CoA hydratase domain-containing protein 1
    methylmalonyl-CoA decarboxylase
    NP_001007735.1
    XP_006227808.3
    XP_006227809.1
    XP_063122135.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007734.1 → NP_001007735.1  ethylmalonyl-CoA decarboxylase isoform 1

      See identical proteins and their annotated locations for NP_001007735.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079052
      UniProtKB/Swiss-Prot
      Q6AYG5
      UniProtKB/TrEMBL
      A0A8L2UIU5, A6JUT5
      Related
      ENSRNOP00000015440.5, ENSRNOT00000015440.6
      Conserved Domains (1) summary
      cd06558
      Location:52 → 243
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    2. NM_001429129.1 → NP_001416058.1  ethylmalonyl-CoA decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q6AYG5
      UniProtKB/TrEMBL
      A0A8L2UIU5, A6JUT5

    3. NM_001429130.1 → NP_001416059.1  ethylmalonyl-CoA decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q6AYG5
      UniProtKB/TrEMBL
      A0A8L2UIU5, A6JUT5

    4. NM_001429131.1 → NP_001416060.1  ethylmalonyl-CoA decarboxylase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      30304968..30355957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227746.4 → XP_006227808.3  ethylmalonyl-CoA decarboxylase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AT16
      Related
      ENSRNOP00000097635.1, ENSRNOT00000107658.2

    2. XM_006227747.5 → XP_006227809.1  ethylmalonyl-CoA decarboxylase isoform X3

      Conserved Domains (1) summary
      cd06558
      Location:52 → 243
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    3. XM_063266065.1 → XP_063122135.1  ethylmalonyl-CoA decarboxylase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYG5.1 GenPept UniProtKB/Swiss-Prot:Q6AYG5

    Gene LinkOut

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