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    Elmo1 engulfment and cell motility 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361251, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elmo1provided by RGD
    Official Full Name
    engulfment and cell motility 1provided by RGD
    Primary source
    RGD:1308182
    See related
    EnsemblRapid:ENSRNOG00000059705 AllianceGenome:RGD:1308182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ELMO1s
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse and postsynapse. Orthologous to human ELMO1 (engulfment and cell motility 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 88.0), Spleen (RPKM 74.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elmo1 in Genome Data Viewer
    Location:
    17q11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (48982188..49518525, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (44286495..44822668, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (46352102..46888788, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 11 Neighboring gene FUS RNA binding protein, pseudogene 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene keratin 18, pseudogene 6 Neighboring gene G protein-coupled receptor 141

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons. Blazejczyk M, et al. Mol Neurobiol, 2017 May. PMID 26993296, Free PMC Article
    2. ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs. Shimazaki A, et al. Kidney Int, 2006 Nov. PMID 17021600
    3. The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons. Kim JY, et al. J Biol Chem, 2011 Oct 28. PMID 21900250, Free PMC Article
    4. Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. Li W, et al. J Biol Chem, 2018 May 18. PMID 29615491, Free PMC Article
    5. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Brugnera E, et al. Nat Cell Biol, 2002 Aug. PMID 12134158

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. prolonged overexpression of Elmo1 in cultured hippocampal neurons increased axonal growth, decreased dendritic spine density, and affected their shape.
      Title: Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons.
    2. The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
      Title: The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
    3. Cell adhesion to extracellular matrix proteins was considerably inhibited in cells overexpressing ELMO1. This suggest that ELMO1 contributes to the development and progression of chronic glomerular injury.
      Title: ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs.
    4. RhoG activates Rac1 through Elmo and Dock180 to control cell morphology.
      Title: RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin filament-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of guanyl-nucleotide exchange factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of guanyl-nucleotide exchange factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    engulfment and cell motility protein 1
    Names
    engulfment and cell motility 1 splice 1
    engulfment and cell motility 1, ced-12 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395578.1 → NP_001382507.1  engulfment and cell motility protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6KN57, D3ZY46
      Related
      ENSRNOP00000073757.3, ENSRNOT00000090663.3
      Conserved Domains (3) summary
      cd13359
      Location:546 → 675
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:303 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 279
      DUF3361; Domain of unknown function (DUF3361)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      48982188..49518525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276615.1 → XP_063132685.1  engulfment and cell motility protein 1 isoform X2

      UniProtKB/TrEMBL
      A6KN57, D3ZY46

    2. XM_063276610.1 → XP_063132680.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZY46, G8CYZ7

    3. XM_063276616.1 → XP_063132686.1  engulfment and cell motility protein 1 isoform X2

      UniProtKB/TrEMBL
      A6KN57, D3ZY46
      Related
      ENSRNOP00000109172.1, ENSRNOT00000129149.1

    4. XM_063276611.1 → XP_063132681.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZY46, G8CYZ7

    5. XM_063276609.1 → XP_063132679.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZY46, G8CYZ7
      Related
      ENSRNOP00000104986.1, ENSRNOT00000167945.1

    6. XM_063276614.1 → XP_063132684.1  engulfment and cell motility protein 1 isoform X2

      UniProtKB/TrEMBL
      A6KN57, D3ZY46

    7. XM_063276612.1 → XP_063132682.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZY46, G8CYZ7

    RNA

    1. XR_010058900.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108415.1: Suppressed sequence

      Description
      NM_001108415.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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