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    Cdc14b cell division cycle 14B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc14bprovided by RGD
    Official Full Name
    cell division cycle 14Bprovided by RGD
    Primary source
    RGD:1311163
    See related
    EnsemblRapid:ENSRNOG00000018999 AllianceGenome:RGD:1311163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including positive regulation of ubiquitin protein ligase activity; protein dephosphorylation; and regulation of cell cycle process. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm; nucleolus; and spindle. Orthologous to several human genes including CDC14B (cell division cycle 14B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 216.9), Kidney (RPKM 112.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc14b in Genome Data Viewer
    Location:
    17p14
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (850272..938972)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (844686..934787)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (1709703..1797732, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene peroxiredoxin like 2C Neighboring gene transfer RNA serine (anticodon AGA) 40 Neighboring gene uncharacterized LOC134482653 Neighboring gene U4 spliceosomal RNA Neighboring gene hyaluronan binding protein 4 Neighboring gene zinc finger protein 367

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of CDC14B expression in clear cell renal cell carcinoma: meta-analysis of microarray data sets. Kim Y, et al. Am J Clin Pathol, 2014 Apr. PMID 24619757
    2. Early-onset aging and defective DNA damage response in Cdc14b-deficient mice. Wei Z, et al. Mol Cell Biol, 2011 Apr. PMID 21262768, Free PMC Article
    3. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. Li L, et al. J Biol Chem, 1997 Nov 21. PMID 9367992
    4. The writers, readers, and functions of the RNA polymerase II C-terminal domain code. Jeronimo C, et al. Chem Rev, 2013 Nov 13. PMID 23837720
    5. Updating the RNA polymerase CTD code: adding gene-specific layers. Egloff S, et al. Trends Genet, 2012 Jul. PMID 22622228

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of exit from mitosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase CDC14B
    Names
    CDC14 cell division cycle 14 homolog B
    NP_001101874.1
    NP_001402601.1
    NP_001402602.1
    NP_001402603.1
    XP_038951756.1
    XP_038951758.1
    XP_038951761.1
    XP_038951764.1
    XP_038951765.1
    XP_038951766.1
    XP_038951767.1
    XP_038951768.1
    XP_038951769.1
    XP_038951770.1
    XP_038951771.2
    XP_038951773.1
    XP_063132612.1
    XP_063132613.1
    XP_063132615.1
    XP_063132616.1
    XP_063132617.1
    XP_063132618.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108404.4 → NP_001101874.1  dual specificity protein phosphatase CDC14B isoform 1

      See identical proteins and their annotated locations for NP_001101874.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I5ZZU6, A6KQD8, F1M567
      Related
      ENSRNOP00000101802.1, ENSRNOT00000124350.1
      Conserved Domains (2) summary
      pfam14671
      Location:54 → 188
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:246 → 360
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_001415672.1 → NP_001402601.1  dual specificity protein phosphatase CDC14B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I5ZZU6, A0A8I6GMP1

    3. NM_001415673.2 → NP_001402602.1  dual specificity protein phosphatase CDC14B isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I5YC46, A0A8I5ZZU6
      Related
      ENSRNOP00000077998.2, ENSRNOT00000114178.2

    4. NM_001415674.2 → NP_001402603.1  dual specificity protein phosphatase CDC14B isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I5ZNF2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      850272..938972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095841.2 → XP_038951769.1  dual specificity protein phosphatase CDC14B isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZZU6
      Related
      ENSRNOP00000085712.2, ENSRNOT00000119773.2
      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    2. XM_039095830.2 → XP_038951758.1  dual specificity protein phosphatase CDC14B isoform X5

      UniProtKB/TrEMBL
      A0A0G2K7S1, A0A8I5ZZU6
      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    3. XM_063276548.1 → XP_063132618.1  dual specificity protein phosphatase CDC14B isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZZU6

    4. XM_039095837.2 → XP_038951765.1  dual specificity protein phosphatase CDC14B isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZZU6
      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    5. XM_039095838.2 → XP_038951766.1  dual specificity protein phosphatase CDC14B isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZZU6
      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    6. XM_039095828.2 → XP_038951756.1  dual specificity protein phosphatase CDC14B isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZU6, A0A8I6AK31, A6KQD7
      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    7. XM_039095836.2 → XP_038951764.1  dual specificity protein phosphatase CDC14B isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZZU6
      Related
      ENSRNOP00000111650.1, ENSRNOT00000135078.1
      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    8. XM_039095840.2 → XP_038951768.1  dual specificity protein phosphatase CDC14B isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZZU6
      Related
      ENSRNOP00000038515.7, ENSRNOT00000033017.8
      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    9. XM_063276542.1 → XP_063132612.1  dual specificity protein phosphatase CDC14B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZU6

    10. XM_063276546.1 → XP_063132616.1  dual specificity protein phosphatase CDC14B isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZZU6

    11. XM_039095833.2 → XP_038951761.1  dual specificity protein phosphatase CDC14B isoform X6

      UniProtKB/TrEMBL
      A0A8I5YC46, A0A8I5ZZU6
      Related
      ENSRNOP00000097799.2, ENSRNOT00000119245.2
      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    12. XM_039095845.2 → XP_038951773.1  dual specificity protein phosphatase CDC14B isoform X16

      Conserved Domains (2) summary
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
      cl28904
      Location:199 → 243
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    13. XM_063276547.1 → XP_063132617.1  dual specificity protein phosphatase CDC14B isoform X12

      Related
      ENSRNOP00000074320.3, ENSRNOT00000079742.3

    14. XM_039095842.2 → XP_038951770.1  dual specificity protein phosphatase CDC14B isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZNF2
      Conserved Domains (2) summary
      cd14499
      Location:162 → 335
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:11 → 153
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    15. XM_039095839.2 → XP_038951767.1  dual specificity protein phosphatase CDC14B isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZZU6
      Related
      ENSRNOP00000079866.2, ENSRNOT00000095758.2
      Conserved Domains (2) summary
      cd14499
      Location:162 → 335
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:11 → 153
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    16. XM_063276543.1 → XP_063132613.1  dual specificity protein phosphatase CDC14B isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZU6

    17. XM_063276545.1 → XP_063132615.1  dual specificity protein phosphatase CDC14B isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZU6

    18. XM_039095843.2 → XP_038951771.2  dual specificity protein phosphatase CDC14B isoform X15

    RNA

    1. XR_005495291.2 RNA Sequence

    2. XR_005495292.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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