Dmtn dematin actin binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dmtnprovided by RGD
Official Full Name: dematin actin binding proteinprovided by RGD
Primary source: RGD:1311419
See related: EnsemblRapid:ENSRNOG00000012273 AllianceGenome:RGD:1311419
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Epb49; Epb4.9
Summary: Predicted to enable actin filament binding activity; signaling receptor binding activity; and spectrin binding activity. Predicted to be involved in several processes, including negative regulation of cell-substrate adhesion; negative regulation of protein phosphorylation; and regulation of plasma membrane bounded cell projection assembly. Predicted to be located in several cellular components, including cytoskeleton; platelet dense tubular network membrane; and postsynaptic density. Predicted to be active in actin cytoskeleton; plasma membrane; and synapse. Orthologous to human DMTN (dematin actin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 220.0), Brain (RPKM 165.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (52087667..52111956, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (45677974..45702261, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (52292762..52320385, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH129121 (e-PCR)
- UniSTS:212429

AU047935 (e-PCR)
- UniSTS:110033

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum tubular network organization	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum tubular network organization	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte development	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in smooth endoplasmic reticulum calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in smooth endoplasmic reticulum calcium ion homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in cell projection membrane	ISO Inferred from Sequence Orthology more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in platelet dense tubular network membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in smooth endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in spectrin-associated cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dematin

Names: erythrocyte membrane protein band 4.9 (dematin); erythrocyte protein band 4.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001394746.1 → NP_001381675.1 dematin isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

Related

ENSRNOP00000097697.2, ENSRNOT00000106565.2

Conserved Domains (2) summary

smart00153
Location:370 → 405

VHP; Villin headpiece domain

pfam16182
Location:8 → 369

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001394747.1 → NP_001381676.1 dematin isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6HTM3, D4A559

Related

ENSRNOP00000059386.2, ENSRNOT00000067776.5

Conserved Domains (2) summary

smart00153
Location:348 → 383

VHP; Villin headpiece domain

pfam16182
Location:8 → 347

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001394748.1 → NP_001381677.1 dematin isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A0A8I5ZXT2

Related

ENSRNOP00000084709.1, ENSRNOT00000097002.2

Conserved Domains (2) summary

smart00153
Location:345 → 380

VHP; Villin headpiece domain

pfam16182
Location:7 → 344

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

52087667..52111956 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108385.1: Suppressed sequence

Description

NM_001108385.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.