Cpeb2 cytoplasmic polyadenylation element binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpeb2provided by RGD
Official Full Name: cytoplasmic polyadenylation element binding protein 2provided by RGD
Primary source: RGD:1307485
See related: EnsemblRapid:ENSRNOG00000005043 AllianceGenome:RGD:1307485
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GTPase inhibitor activity; mRNA regulatory element binding translation repressor activity; and ribosome binding activity. Involved in negative regulation of cytoplasmic translational elongation. Located in cytoplasm and nucleus. Orthologous to human CPEB2 (cytoplasmic polyadenylation element binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 130.6), Brain (RPKM 104.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (71999958..72056012, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (67787503..67839973, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (72327929..72382519, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA regulatory element binding translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA regulatory element binding translation repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA regulatory element binding translation repressor activity	ISO Inferred from Sequence Orthology more info
enables poly-pyrimidine tract binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal large subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal small subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation factor activity, RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytoplasmic translational elongation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of translational elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation at synapse, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in ribosome	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytoplasmic polyadenylation element-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

71999958..72056012 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092809.2 → XP_038948737.1 cytoplasmic polyadenylation element-binding protein 2 isoform X13

Related

ENSRNOP00000101828.1, ENSRNOT00000127150.1

Conserved Domains (3) summary

pfam16366
Location:910 → 971

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:727 → 818

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:835 → 915

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_039092807.2 → XP_038948735.1 cytoplasmic polyadenylation element-binding protein 2 isoform X11

Conserved Domains (3) summary

pfam16366
Location:918 → 979

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:735 → 826

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:843 → 923

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_039092804.2 → XP_038948732.1 cytoplasmic polyadenylation element-binding protein 2 isoform X8

Conserved Domains (3) summary

pfam16366
Location:932 → 993

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:749 → 840

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:857 → 937

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_063273830.1 → XP_063129900.1 cytoplasmic polyadenylation element-binding protein 2 isoform X14

Related

ENSRNOP00000106754.1, ENSRNOT00000158644.1
XM_039092802.2 → XP_038948730.1 cytoplasmic polyadenylation element-binding protein 2 isoform X6

UniProtKB/TrEMBL

A0A8I5Y989

Related

ENSRNOP00000076988.1, ENSRNOT00000119809.2

Conserved Domains (3) summary

pfam16366
Location:940 → 1001

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:757 → 848

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:865 → 945

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_039092799.2 → XP_038948727.1 cytoplasmic polyadenylation element-binding protein 2 isoform X4

UniProtKB/TrEMBL

D3ZHK8

Conserved Domains (3) summary

pfam16366
Location:948 → 1009

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:765 → 856

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:873 → 953

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_039092797.2 → XP_038948725.1 cytoplasmic polyadenylation element-binding protein 2 isoform X2

Related

ENSRNOP00000107879.1, ENSRNOT00000159657.1

Conserved Domains (3) summary

pfam16366
Location:962 → 1023

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:779 → 870

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:887 → 967

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_039092808.2 → XP_038948736.1 cytoplasmic polyadenylation element-binding protein 2 isoform X12

Conserved Domains (3) summary

pfam16366
Location:913 → 974

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:730 → 821

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:838 → 918

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_039092806.2 → XP_038948734.1 cytoplasmic polyadenylation element-binding protein 2 isoform X10

Conserved Domains (3) summary

pfam16366
Location:921 → 982

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:738 → 829

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:846 → 926

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_039092803.2 → XP_038948731.1 cytoplasmic polyadenylation element-binding protein 2 isoform X7

UniProtKB/TrEMBL

A0A0G2K520

Related

ENSRNOP00000073259.2, ENSRNOT00000082653.3

Conserved Domains (3) summary

pfam16366
Location:935 → 996

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:752 → 843

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:860 → 940

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_039092801.2 → XP_038948729.1 cytoplasmic polyadenylation element-binding protein 2 isoform X5

Conserved Domains (3) summary

pfam16366
Location:943 → 1004

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:760 → 851

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:868 → 948

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_039092798.2 → XP_038948726.1 cytoplasmic polyadenylation element-binding protein 2 isoform X3

Related

ENSRNOP00000006727.9, ENSRNOT00000006727.9

Conserved Domains (3) summary

pfam16366
Location:951 → 1012

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:768 → 859

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:876 → 956

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_039092805.2 → XP_038948733.1 cytoplasmic polyadenylation element-binding protein 2 isoform X9

Conserved Domains (3) summary

pfam16366
Location:965 → 1004

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:782 → 873

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:890 → 970

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_039092796.2 → XP_038948724.1 cytoplasmic polyadenylation element-binding protein 2 isoform X1

Conserved Domains (3) summary

pfam16366
Location:965 → 1026

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:782 → 873

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:890 → 970

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_063273833.1 → XP_063129903.1 cytoplasmic polyadenylation element-binding protein 2 isoform X18
XM_063273832.1 → XP_063129902.1 cytoplasmic polyadenylation element-binding protein 2 isoform X17
XM_063273831.1 → XP_063129901.1 cytoplasmic polyadenylation element-binding protein 2 isoform X16
XM_039092810.2 → XP_038948738.1 cytoplasmic polyadenylation element-binding protein 2 isoform X15

UniProtKB/TrEMBL

A6IJP7

Conserved Domains (3) summary

pfam16366
Location:439 → 500

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:256 → 347

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:364 → 444

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108361.1: Suppressed sequence

Description

NM_001108361.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: CPEB2 (GeneID:132864).