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    Slc25a39 solute carrier family 25, member 39 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360636, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25a39provided by RGD
    Official Full Name
    solute carrier family 25, member 39provided by RGD
    Primary source
    RGD:1306193
    See related
    EnsemblRapid:ENSRNOG00000020994 AllianceGenome:RGD:1306193
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306193
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity and glutathione transmembrane transporter activity. Predicted to be involved in cellular response to iron ion and glutathione import into mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human SLC25A39 (solute carrier family 25 member 39). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 597.3), Testes (RPKM 484.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a39 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87862630..87867626, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87362494..87367358, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90351899..90356905, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene partner of NOB1 homolog (S. cerevisiae), pseudogene 1 Neighboring gene RUN domain containing 3A Neighboring gene granulin precursor Neighboring gene family with sequence similarity 171, member A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to iron ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to iron ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione import into mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione import into mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione import into mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial glutathione transporter SLC25A39; probable mitochondrial glutathione transporter SLC25A39

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024792.1 → NP_001019963.1  mitochondrial glutathione transporter SLC25A39

      See identical proteins and their annotated locations for NP_001019963.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097349
      UniProtKB/Swiss-Prot
      Q4V8K4
      UniProtKB/TrEMBL
      A0A8L2QFK6, A6HJJ4
      Related
      ENSRNOP00000028496.6, ENSRNOT00000028496.6
      Conserved Domains (2) summary
      pfam00153
      Location:254 → 350
      Mito_carr; Mitochondrial carrier protein
      pfam18398
      Location:71 → 94
      CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      87862630..87867626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247374.5 → XP_006247436.1  probable mitochondrial glutathione transporter SLC25A39 isoform X1

      See identical proteins and their annotated locations for XP_006247436.1

      UniProtKB/Swiss-Prot
      Q4V8K4
      UniProtKB/TrEMBL
      A0A8L2QFK6, A6HJJ4
      Conserved Domains (2) summary
      pfam00153
      Location:254 → 350
      Mito_carr; Mitochondrial carrier protein
      pfam18398
      Location:71 → 94
      CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

    2. XM_006247376.4 → XP_006247438.1  probable mitochondrial glutathione transporter SLC25A39 isoform X1

      See identical proteins and their annotated locations for XP_006247438.1

      UniProtKB/Swiss-Prot
      Q4V8K4
      UniProtKB/TrEMBL
      A0A8L2QFK6, A6HJJ4
      Conserved Domains (2) summary
      pfam00153
      Location:254 → 350
      Mito_carr; Mitochondrial carrier protein
      pfam18398
      Location:71 → 94
      CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

    3. XM_039086411.2 → XP_038942339.1  probable mitochondrial glutathione transporter SLC25A39 isoform X1

      UniProtKB/Swiss-Prot
      Q4V8K4
      UniProtKB/TrEMBL
      A0A8L2QFK6, A6HJJ4
      Conserved Domains (2) summary
      pfam00153
      Location:254 → 350
      Mito_carr; Mitochondrial carrier protein
      pfam18398
      Location:71 → 94
      CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

    4. XM_039086412.1 → XP_038942340.1  probable mitochondrial glutathione transporter SLC25A39 isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:153 → 249
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8K4.1 GenPept UniProtKB/Swiss-Prot:Q4V8K4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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