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    Cwc25 CWC25 spliceosome-associated protein homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360613, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cwc25provided by RGD
    Official Full Name
    CWC25 spliceosome-associated protein homologprovided by RGD
    Primary source
    RGD:1305258
    See related
    EnsemblRapid:ENSRNOG00000004091 AllianceGenome:RGD:1305258
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc49; RGD1305258
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of U2-type catalytic step 1 spliceosome. Orthologous to human CWC25 (CWC25 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 50.7), Spleen (RPKM 45.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cwc25 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83232052..83256722, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82735698..82760373, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85684898..85709568, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA threonine (anticodon AGU) 11 Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 beta Neighboring gene transfer RNA cysteine (anticodon GCA) 33 Neighboring gene sperm microtubule associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of a human catalytic step I spliceosome. Zhan X, et al. Science, 2018 Feb 2. PMID 29301961
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 1 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA-splicing factor CWC25 homolog
    Names
    coiled-coil domain containing 49

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108295.3 → NP_001101765.1  pre-mRNA-splicing factor CWC25 homolog

      See identical proteins and their annotated locations for NP_001101765.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HIM6, B4F7A4, G3V6I3
      Related
      ENSRNOP00000005426.4, ENSRNOT00000005426.8
      Conserved Domains (2) summary
      pfam10197
      Location:11 → 37
      Cir_N; N-terminal domain of CBF1 interacting co-repressor CIR
      pfam12542
      Location:67 → 156
      CWC25; Pre-mRNA splicing factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83232052..83256722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086393.2 → XP_038942321.1  pre-mRNA-splicing factor CWC25 homolog isoform X1

      UniProtKB/TrEMBL
      B4F7A4
      Conserved Domains (1) summary
      pfam12542
      Location:15 → 105
      CWC25; Pre-mRNA splicing factor
    Nucleotide Protein Strain
    Heading Accession and Version

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