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    GstE13 Glutathione S transferase E13 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35928, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GstE13provided by FlyBase
    Official Full Name
    Glutathione S transferase E13provided by FlyBase
    Primary source
    FLYBASE:FBgn0033381
    Locus tag
    Dmel_CG11784
    See related
    AllianceGenome:FB:FBgn0033381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD22317; CG11784; Dmel\CG11784; gste13; GSTE13
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstE13 in Genome Data Viewer
    Location:
    45A9-45A9; 2-60 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9122125..9123309)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5009630..5010814)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Suppressor of variegation 2-10 Neighboring gene Phosphorylated adaptor for RNA export Neighboring gene uncharacterized protein Neighboring gene alpha/beta hydrolase 1 Neighboring gene alicorn Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site. Wongsantichon J, et al. Biosci Rep, 2015 Oct 20. PMID 26487708, Free PMC Article
    2. Structural and Thermodynamic Insights into Dimerization Interfaces of Drosophila Glutathione Transferases. Schwartz M, et al. Biomolecules, 2024 Jun 26. PMID 39062472, Free PMC Article
    3. Expression Patterns of Drosophila Melanogaster Glutathione Transferases. Gonis E, et al. Insects, 2022 Jul 7. PMID 35886788, Free PMC Article
    4. A regulatory role for the unstructured C-terminal domain of the CtBP transcriptional corepressor. Raicu AM, et al. J Biol Chem, 2024 Jan. PMID 38000659, Free PMC Article
    5. Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway. Flaherty MS, et al. Dev Dyn, 2009 Sep. PMID 19504457, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase E13
    Names
    CG11784-PA
    CG11784-PB
    GstE13-PA
    GstE13-PB
    NP_001188889.1
    NP_610457.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9122125..9123309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201960.1 → NP_001188889.1  glutathione S transferase E13, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188889.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVI6
      Conserved Domains (2) summary
      cd03177
      Location:92 → 211
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      cd03045
      Location:4 → 78
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...

    2. NM_136613.3 → NP_610457.1  glutathione S transferase E13, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610457.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVI6
      Related
      FBpp0087660
      Conserved Domains (2) summary
      cd03177
      Location:92 → 211
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      cd03045
      Location:4 → 78
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JVI6 Q7JVI6

    Gene LinkOut

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