drosha drosha [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: droshaprovided by FlyBase
Official Full Name: droshaprovided by FlyBase
Primary source: FLYBASE:FBgn0026722
Locus tag: Dmel_CG8730
See related: AllianceGenome:FB:FBgn0026722
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8730; Dmel\CG8730; Drosha; DROSHA
Summary: Predicted to enable double-stranded RNA binding activity and ribonuclease III activity. Involved in several processes, including germarium-derived egg chamber formation; miRNA processing; and mushroom body development. Part of microprocessor complex. Used to study brain disease. Orthologous to human DROSHA (drosha ribonuclease III). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 43F2-43F3; 2-57 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7932429..7936840)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3819934..3824345)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo.
Title: Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo.
Drosha and Pasha are required for coordinated development of somatic and germ cell precursors in the larval ovary. Loss of Drosha or Pasha function perturbs somatic precursor development, causing defects in formation of terminal filaments. Drosha-controlled miRNAs including miR-8, miR-14, miR-33, miR-184, miR-317 and let-7-C function in gonadogenesis.
Title: MicroRNA-dependent roles of Drosha and Pasha in the Drosophila larval ovary morphogenesis.
We propose that Drosha represents a unique and conserved arm of the cellular defenses used to combat virus infection.
Title: Drosha as an interferon-independent antiviral factor.
report clear phenotypic differences between drosha and pasha/dgcr8 null alleles in two postembryonic lineages in the Drosophila brain
Title: Drosha-independent DGCR8/Pasha pathway regulates neuronal morphogenesis.
Excess Drosha cleaves pasha/DGCR8 primary transcripts and leads to a reduction in pasha/DGCR8 mRNA levels and Pasha/DGCR8 synthesis.
Title: Genome-wide identification of targets of the drosha-pasha/DGCR8 complex.
cleavage is catalysed by Drosha, a nuclease of the RNase III family, which acts on primary miRNA transcripts (pri-miRNAs) in the nucleus
Title: Processing of primary microRNAs by the Microprocessor complex.
A genome-wide analysis of mRNAs regulated by drosha was performed.
Title: Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ribonuclease III activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonuclease III activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in germarium-derived female germ-line cyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in pre-miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in pre-miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in primary miRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in primary miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in salivary gland histolysis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of microprocessor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of microprocessor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: drosha

Names: CG8730-PA; drosha-PA

NP_477436.1

EC 3.1.26.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

7932429..7936840

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058088.4 → NP_477436.1 drosha [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477436.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KNF1, Q960Y4

Related

FBpp0087926

Conserved Domains (5) summary

smart00535
Location:990 → 1117

RIBOc; Ribonuclease III family

COG0571
Location:738 → 974

Rnc; dsRNA-specific ribonuclease [Transcription]

PRK00102
Location:973 → 1196

rnc; ribonuclease III; Reviewed

cd00048
Location:1125 → 1196

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam12413
Location:64 → 136

DLL_N; Homeobox protein distal-less-like N terminal