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    lsy-12 Histone acetyltransferase lsy-12 [ Caenorhabditis elegans ]

    Gene ID: 3565873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lsy-12
    Official Full Name
    Histone acetyltransferase lsy-12
    Primary source
    WormBase:WBGene00045419
    Locus tag
    CELE_R07B5.9
    See related
    AllianceGenome:WB:WBGene00045419
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity; histone H4K16 acetyltransferase activity; and transcription coregulator activity. Involved in cell fate specification; maintenance of left/right asymmetry; and positive regulation of gene expression. Predicted to be located in chromatin. Predicted to be part of MSL complex; NSL complex; and NuA4 histone acetyltransferase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lsy-12 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    17
    Sequence:
    Chromosome: V; NC_003283.11 (9846157..9859963, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Serpentine Receptor, class U Neighboring gene Serpentine Receptor, class U Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Serpentine Receptor, class AB (class A-like) Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class AB (Class A-like) Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparing platforms for C. elegans mutant identification using high-throughput whole-genome sequencing. Shen Y, et al. PLoS One, 2008. PMID 19107202, Free PMC Article
    2. Maintenance of neuronal laterality in Caenorhabditis elegans through MYST histone acetyltransferase complex components LSY-12, LSY-13 and LIN-49. O'Meara MM, et al. Genetics, 2010 Dec. PMID 20923973, Free PMC Article
    3. Analysis of multiple ethyl methanesulfonate-mutagenized Caenorhabditis elegans strains by whole-genome sequencing. Sarin S, et al. Genetics, 2010 Jun. PMID 20439776, Free PMC Article
    4. Genetic screens for Caenorhabditis elegans mutants defective in left/right asymmetric neuronal fate specification. Sarin S, et al. Genetics, 2007 Aug. PMID 17717195, Free PMC Article
    5. Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Sarin S, et al. Nat Methods, 2008 Oct. PMID 18677319, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Histone acetyltransferase lsy-12
    NP_001256145.1
    • Partially confirmed by transcript evidence
    NP_001256146.1
    • Confirmed by transcript evidence
    NP_001256147.1
    • Partially confirmed by transcript evidence
    NP_001263847.1
    • Partially confirmed by transcript evidence
    NP_001263848.1
    • Confirmed by transcript evidence
    NP_001263849.1
    • Partially confirmed by transcript evidence
    NP_001359576.1
    • Confirmed by transcript evidence
    NP_001360180.1
    • Confirmed by transcript evidence
    NP_001368168.1
    • Confirmed by transcript evidence
    NP_001379520.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9846157..9859963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276920.4 → NP_001263849.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263849.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D7SFM3, G5EBH5, G5EGP0, G5EGU3, K8ERR8, K8ES81, K8ESF3, K8F7U3, L8E6K3, Q21789
      Conserved Domains (2) summary
      pfam01853
      Location:605 → 786
      MOZ_SAS; MOZ/SAS family
      cl17182
      Location:550 → 783
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    2. NM_001276918.3 → NP_001263847.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263847.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8F7U3
      Conserved Domains (2) summary
      pfam01853
      Location:560 → 741
      MOZ_SAS; MOZ/SAS family
      cl17182
      Location:505 → 738
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    3. NM_001373081.2 → NP_001360180.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      pfam01853
      Location:269 → 447
      MOZ_SAS; MOZ/SAS family
      pfam17772
      Location:211 → 264
      zf-MYST; MYST family zinc finger domain

    4. NM_001269216.3 → NP_001256145.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256145.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGP0
      Conserved Domains (2) summary
      pfam01853
      Location:560 → 741
      MOZ_SAS; MOZ/SAS family
      cl17182
      Location:505 → 738
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    5. NM_001269218.3 → NP_001256147.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256147.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBH5
      Conserved Domains (2) summary
      pfam01853
      Location:605 → 786
      MOZ_SAS; MOZ/SAS family
      cl17182
      Location:550 → 783
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    6. NM_001269217.3 → NP_001256146.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256146.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGU3
      Conserved Domains (2) summary
      pfam01853
      Location:276 → 457
      MOZ_SAS; MOZ/SAS family
      cl17182
      Location:221 → 454
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    7. NM_001276919.3 → NP_001263848.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8ES81
      Conserved Domains (2) summary
      pfam01853
      Location:276 → 457
      MOZ_SAS; MOZ/SAS family
      cl17182
      Location:221 → 454
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    8. NM_001392586.1 → NP_001379520.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      pfam01853
      Location:269 → 450
      MOZ_SAS; MOZ/SAS family
      pfam17772
      Location:211 → 264
      zf-MYST; MYST family zinc finger domain

    9. NM_001373082.2 → NP_001359576.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      pfam01853
      Location:269 → 447
      MOZ_SAS; MOZ/SAS family
      pfam17772
      Location:211 → 264
      zf-MYST; MYST family zinc finger domain

    10. NM_001380733.2 → NP_001368168.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      pfam01853
      Location:269 → 450
      MOZ_SAS; MOZ/SAS family
      pfam17772
      Location:211 → 264
      zf-MYST; MYST family zinc finger domain
    Nucleotide Protein
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