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    gopc-1 PDZ domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565651, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gopc-1
    Official Full Name
    PDZ domain-containing protein
    Primary source
    WormBase:WBGene00014101
    Locus tag
    CELE_ZK849.2
    See related
    AllianceGenome:WB:WBGene00014101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity. Predicted to be involved in negative regulation of protein localization to cell surface. Predicted to be active in Golgi apparatus; membrane; and trans-Golgi network transport vesicle. Orthologous to human GOPC (golgi associated PDZ and coiled-coil motif containing). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gopc-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (14185628..14196295, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Very-long-chain 3-oxoacyl-CoA synthase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Axin-like protein pry-1 Neighboring gene ncRNA Neighboring gene PDZ domain-containing protein Neighboring gene NADH dehydrogenase subunit 1 Neighboring gene Bestrophin homolog 26 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein localization to cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PDZ domain-containing protein
    NP_001021877.2
    • Confirmed by transcript evidence
    NP_001021878.2
    • Confirmed by transcript evidence
    NP_001122569.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14185628..14196295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026706.4 → NP_001021877.2  PDZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021877.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18302
      Conserved Domains (2) summary
      cd00992
      Location:284 → 353
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02168
      Location:42 → 228
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_001026707.5 → NP_001021878.2  PDZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021878.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q564T0
      Conserved Domains (2) summary
      cd00992
      Location:282 → 351
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00529
      Location:90 → 211
      HlyD; HlyD membrane-fusion protein of T1SS

    3. NM_001129097.5 → NP_001122569.1  PDZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5JYY2
      Conserved Domains (2) summary
      cd00992
      Location:260 → 329
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02168
      Location:18 → 204
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version

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