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    geminin geminin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35563, updated on 17-Dec-2024

    Summary

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    Official Symbol
    gemininprovided by FlyBase
    Official Full Name
    gemininprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033081
    Locus tag
    Dmel_CG3183
    See related
    AllianceGenome:FB:FBgn0033081
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0257455.1; CG3183; Dm geminin; Dm Geminin; Dmel\CG3183; gem; Gem; Geminin; l(2)k14019; v(2)k09107
    Summary
    Involved in endomitotic cell cycle; negative regulation of DNA replication; and regulation of syncytial blastoderm mitotic cell cycle. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; larval imaginal tissue; and optic neuroblast. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 6. Orthologous to human GMNN (geminin DNA replication inhibitor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See geminin in Genome Data Viewer
    Location:
    42C2-42C2; 2-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6655463..6656594, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2542968..2544099, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Death executioner Bcl-2 Neighboring gene Optix-binding protein Neighboring gene scrambled Neighboring gene DNA polymerase interacting tpr containing protein of 47kD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preferential re-replication of Drosophila heterochromatin in the absence of geminin. Ding Q, et al. PLoS Genet, 2010 Sep 9. PMID 20838463, Free PMC Article
    2. Cellular checkpoint mechanisms monitoring proper initiation of DNA replication. Machida YJ, et al. J Biol Chem, 2005 Feb 25. PMID 15591064
    3. Polyploidy in the adult Drosophila brain. Nandakumar S, et al. Elife, 2020 Aug 25. PMID 32840209, Free PMC Article
    4. Cell cycle defects in polyhomeotic mutants are caused by abrogation of the DNA damage checkpoint. Beck SA, et al. Dev Biol, 2010 Mar 15. PMID 20045683
    5. Control of DNA replication and chromosome ploidy by geminin and cyclin A. Mihaylov IS, et al. Mol Cell Biol, 2002 Mar. PMID 11865064, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the absence of geminin, limited pre-replicative complex assembly was restricted to the heterochromatin by elevated cyclin A-CDK activity.
      Title: Preferential re-replication of Drosophila heterochromatin in the absence of geminin.
    2. Gem and Brm act antagonistically to modulate the EGFR-Ras-MAPK signaling pathway, by affecting Mek levels during Drosophila development
      Title: Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila.
    3. Down-regulation of APC/C activity results in stabilization of Geminin protein and blocks endocycle progression.
      Title: The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles.
    4. In cycling cells, Dup destruction is coupled to DNA replication and that increased levels of Gem balance elevated Dup levels to prevent pre-replicative complex reformation when Dup degradation fails.
      Title: Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in eggshell chorion gene amplification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in endomitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of syncytial blastoderm mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    geminin
    Names
    CG3183-PA
    CG3183-PB
    geminin-PA
    geminin-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6655463..6656594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136374.4 → NP_610218.1  geminin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610218.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JX41
      Related
      FBpp0085480
      Conserved Domains (1) summary
      pfam07412
      Location:25 → 188
      Geminin; Geminin

    2. NM_001273798.1 → NP_001260727.1  geminin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260727.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JX41
      Conserved Domains (1) summary
      pfam07412
      Location:25 → 188
      Geminin; Geminin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JX41 Q7JX41

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
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