Kir3dl1 killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kir3dl1provided by RGD
Official Full Name: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1provided by RGD
Primary source: RGD:727836
See related: EnsemblRapid:ENSRNOG00000027843 AllianceGenome:RGD:727836
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable molecular adaptor activity. Predicted to be involved in immune response-regulating signaling pathway and natural killer cell mediated cytotoxicity. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Polyomavirus-associated nephropathy; West Nile fever; human immunodeficiency virus infectious disease (multiple); liver disease (multiple); and tuberculosis (multiple). Orthologous to several human genes including KIR3DL1 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1); KIR3DL2 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2); and KIR3DL3 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 7.6), Lung (RPKM 3.8) and 4 other tissues See more
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Genomic context

Location:: 1q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (78756035..78796961, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (69715529..69754050, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (73306564..73345009, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: killer cell immunoglobulin-like receptor 3DL1

Names: killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181479.2 → NP_852144.1 killer cell immunoglobulin-like receptor 3DL1 precursor

See identical proteins and their annotated locations for NP_852144.1

Status: PROVISIONAL

Source sequence(s)

AF527797

UniProtKB/Swiss-Prot

P83556

UniProtKB/TrEMBL

A6KNK5

Related

ENSRNOP00000031521.4, ENSRNOT00000039823.5

Conserved Domains (3) summary

cd05711
Location:121 → 217

Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI

smart00410
Location:127 → 205

IG_like; Immunoglobulin like

cl11960
Location:223 → 313

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

78756035..78796961 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265852.1 → XP_063121922.1 killer cell immunoglobulin-like receptor 3DL1 isoform X2
XM_063265848.1 → XP_063121918.1 killer cell immunoglobulin-like receptor 3DL1 isoform X1