opn4.1 opsin 4.1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: opn4.1provided by ZNC
Official Full Name: opsin 4.1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030314-2
See related: Ensembl:ENSDARG00000007553 AllianceGenome:ZFIN:ZDB-GENE-030314-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: opn4; opn4l; opn4m2
Summary: Enables photoreceptor activity. Acts upstream of or within phospholipase C-activating opsin-mediated signaling pathway and regulation of locomotor rhythm. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; heart; integument; testis; and visual system. Orthologous to human OPN4 (opsin 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (32843133..32846324)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (32859915..32863106)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Opn4m2 labeling shows nuclear localization, which did not change in response to light. opn4m1, opn4m2, gr, per1b, and cry1b presented an oscillatory profile of expression in LD condition. In both DD and LD condition, dexamethasone (DEX) treatment shifted the peak expression of per1b and cry1b transcripts
Title: Dexamethasone Modulates Nonvisual Opsins, Glucocorticoid Receptor, and Clock Genes in Danio rerio ZEM-2S Cells.
The opn4.1 gene is not expressed in the brain until 3 dpf, when transcripts are located at the juncture between the caudal hindbrain and anterior spinal cord, in cells in the ventricular region.
Title: Unexpected diversity and photoperiod dependence of the zebrafish melanopsin system.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables photoreceptor activity	IDA Inferred from Direct Assay more info	PubMed
enables photoreceptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipase C-activating opsin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phototransduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of locomotor rhythm	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: melanopsin-like

Names: mammalian-like melanopsin-2; melanopsin opn4m2; opn4c; opsin 4 (melanopsin); opsin 4, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178289.3 → NP_840074.2 melanopsin-like

See identical proteins and their annotated locations for NP_840074.2

Status: VALIDATED

Source sequence(s)

BC116614

UniProtKB/Swiss-Prot

Q1JPS6, Q8AV31

UniProtKB/TrEMBL

G8Z410

Related

ENSDARP00000002787.7, ENSDART00000018501.9

Conserved Domains (2) summary

pfam00001
Location:81 → 340

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:72 → 284

7tm_4; Olfactory receptor