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    CG10561 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35189, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10561provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002036
    Locus tag
    Dmel_CG10561
    See related
    AllianceGenome:FB:FBgn0002036
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-37Cb; anon-37Cc; anon-37Cd; anon-37Cs; Anon-37Cs; C2; cs; Cs; Dmel\CG10561; l(2)37Cs; ORF1; ORF2; ORF3; TU37C1; TU37C2; TuC1
    Summary
    Predicted to enable polyamine oxidase activity. Located in cytoplasm. Is expressed in several structures, including anterior-posterior subdivision of organism; gonad; and ventral sensory complex primordium. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human PAOX (polyamine oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See CG10561 in Genome Data Viewer
    Location:
    37C1-37C1; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19114401..19116570)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19114401..19116570)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44905 Neighboring gene alpha methyl dopa-resistant Neighboring gene Dopa decarboxylase Neighboring gene Prohibitin 1 Neighboring gene lethal (2) 37Cb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overlapping transcription units in the dopa decarboxylase region of Drosophila. Spencer CA, et al. Nature, 1986 Jul 17-23. PMID 2874495
    2. Analysis of the transcription unit adjacent to the 3'-end of the dopa decarboxylase gene in Drosophila melanogaster. Spencer CA, et al. Dev Biol, 1986 Mar. PMID 3007242
    3. Molecular localization, developmental expression and nucleotide sequence of the alpha-methyldopa hypersensitive gene of Drosophila. Marsh JL, et al. Genetics, 1986 Oct. PMID 3021571, Free PMC Article
    4. Evidence for evolutionary duplication of genes in the dopa decarboxylase region of Drosophila. Eveleth DD, et al. Genetics, 1986 Oct. PMID 3021572, Free PMC Article
    5. Overlapping transcription units in Drosophila: sequence and structure of the Cs gene. Eveleth DD, et al. Mol Gen Genet, 1987 Sep. PMID 3478553

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyamine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10561-PA
    lethal(2)37Cs
    transcription unit 37C2
    transcription unit No. 2
    NP_476608.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19114401..19116570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057260.4 → NP_476608.1  uncharacterized protein Dmel_CG10561 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476608.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18376, O18377, O18378, O96568, P18487, Q95TY1, Q9VIZ7
      UniProtKB/TrEMBL
      B5RIP2
      Related
      FBpp0080699
      Conserved Domains (2) summary
      pfam01593
      Location:48 → 494
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:43 → 109
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18487.3 P18487

    Gene LinkOut

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