CLEC18A C-type lectin domain family 18 member A [Homo sapiens (human)] - Gene

Summary

Official Symbol: CLEC18Aprovided by HGNC
Official Full Name: C-type lectin domain family 18 member Aprovided by HGNC
Primary source: HGNC:HGNC:30388
See related: Ensembl:ENSG00000157322 MIM:616571; AllianceGenome:HGNC:30388
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRCL; MRCL1; MRLP2
Summary: This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]
Expression: Biased expression in kidney (RPKM 14.8), testis (RPKM 4.0) and 1 other tissue See more
Orthologs: all
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Genomic context

Location:: 16q22.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (69943519..69966623)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (75749365..75773415)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (69984420..69997889)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics.
Title: Human rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics.
Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.
Title: Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.
High CLEC18 serum levels were associated with chronic HCV infection in rheumatic diseases.
Title: Association of C-type lectin 18 levels with extrahepatic manifestations in chronic HCV infection.
The human C-type lectin 18 (clec18) gene cluster, which contains three clec18a, clec18b, and clec18c loci, is located in human chromosome 16q22.
Title: Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.
Plasma CLEC18 levels were correlated with the stage of HBV infection and could predict HBeAg loss and seroconversion in the patients with chronic hepatitis B (CHB) undergoing NUC therapy
Title: The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

RH102328 (e-PCR)
- UniSTS:96662

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables polysaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables polysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in endosome	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-type lectin domain family 18 member A

Names: mannose receptor-like 1; mannose receptor-like protein 2; mannose receptor-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136214.4 → NP_001129686.1 C-type lectin domain family 18 member A precursor

See identical proteins and their annotated locations for NP_001129686.1

Status: REVIEWED

Source sequence(s)

AC026468

Consensus CDS

CCDS10886.1

UniProtKB/Swiss-Prot

A5D8T8, A8K1G9, Q6DCB3, Q7Z5K9, Q96HH2

UniProtKB/TrEMBL

F8W692

Related

ENSP00000484176.1, ENST00000615430.4

Conserved Domains (2) summary

cd00037
Location:310 → 434

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd05380
Location:50 → 183

CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins
NM_001271197.3 → NP_001258126.1 C-type lectin domain family 18 member A precursor

See identical proteins and their annotated locations for NP_001258126.1

Status: REVIEWED

Source sequence(s)

AC026468

Consensus CDS

CCDS10886.1

UniProtKB/Swiss-Prot

A5D8T8, A8K1G9, Q6DCB3, Q7Z5K9, Q96HH2

UniProtKB/TrEMBL

F8W692

Related

ENSP00000454685.1, ENST00000568461.5

Conserved Domains (2) summary

cd00037
Location:310 → 434

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd05380
Location:50 → 183

CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins
NM_001370523.4 → NP_001357452.1 C-type lectin domain family 18 member A precursor

Status: REVIEWED

Source sequence(s)

AC026468

Consensus CDS

CCDS10886.1

UniProtKB/Swiss-Prot

A5D8T8, A8K1G9, Q6DCB3, Q7Z5K9, Q96HH2

UniProtKB/TrEMBL

F8W692

Related

ENSP00000288040.6, ENST00000288040.11

Conserved Domains (2) summary

cd00037
Location:310 → 434

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd05380
Location:50 → 183

CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins
NM_182619.5 → NP_872425.2 C-type lectin domain family 18 member A precursor

See identical proteins and their annotated locations for NP_872425.2

Status: REVIEWED

Source sequence(s)

AC026468

Consensus CDS

CCDS10886.1

UniProtKB/Swiss-Prot

A5D8T8, A8K1G9, Q6DCB3, Q7Z5K9, Q96HH2

UniProtKB/TrEMBL

F8W692

Related

ENSP00000377304.2, ENST00000393701.6

Conserved Domains (2) summary

cd00037
Location:310 → 434

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd05380
Location:50 → 183

CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

69943519..69966623

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047434062.1 → XP_047290018.1 C-type lectin domain family 18 member A isoform X2

UniProtKB/Swiss-Prot

A5D8T8, A8K1G9, Q6DCB3, Q7Z5K9, Q96HH2
XM_047434059.1 → XP_047290015.1 C-type lectin domain family 18 member A isoform X1
XM_047434060.1 → XP_047290016.1 C-type lectin domain family 18 member A isoform X1
XM_047434058.1 → XP_047290014.1 C-type lectin domain family 18 member A isoform X1
XM_017023208.3 → XP_016878697.1 C-type lectin domain family 18 member A isoform X3
XM_047434061.1 → XP_047290017.1 C-type lectin domain family 18 member A isoform X1
XM_047434064.1 → XP_047290020.1 C-type lectin domain family 18 member A isoform X5
XM_047434063.1 → XP_047290019.1 C-type lectin domain family 18 member A isoform X4
XM_047434065.1 → XP_047290021.1 C-type lectin domain family 18 member A isoform X6

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

75749365..75773415

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047446599.1 → XP_047302555.1 C-type lectin domain family 18 member A isoform X7
XM_047446602.1 → XP_047302558.1 C-type lectin domain family 18 member A isoform X2
XM_047446605.1 → XP_047302561.1 C-type lectin domain family 18 member A isoform X8
XM_047446600.1 → XP_047302556.1 C-type lectin domain family 18 member A isoform X7
XM_047446601.1 → XP_047302557.1 C-type lectin domain family 18 member A isoform X7