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    escl escl [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34611, updated on 9-Dec-2024

    Summary

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    Official Symbol
    esclprovided by FlyBase
    Official Full Name
    esclprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032391
    Locus tag
    Dmel_CG5202
    See related
    AllianceGenome:FB:FBgn0032391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5202; CG5202-PA; Dmel\CG5202; ESC; ESC-LIKE; ESC1; Escl; ESCL
    Summary
    Predicted to contribute to nucleosome binding activity. Involved in facultative heterochromatin formation. Part of ESC/E(Z) complex. Is expressed in eye disc; organism; salivary gland; and wing disc. Orthologous to human EED (embryonic ectoderm development). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See escl in Genome Data Viewer
    Location:
    33B5-33B5; 2-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11990927..11992848)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11990927..11992848)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene zucchini Neighboring gene dim gamma-tubulin 2 Neighboring gene transcriptional Adaptor 1-2 Neighboring gene uncharacterized protein Neighboring gene Quetzalcoatl

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila ESC-like can substitute for ESC and becomes required for Polycomb silencing if ESC is absent. Kurzhals RL, et al. Dev Biol, 2008 Jan 1. PMID 18048023, Free PMC Article
    2. Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene. Coleman RT, et al. Science, 2017 Apr 7. PMID 28302795, Free PMC Article
    3. Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster. Rogers RL, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534482, Free PMC Article
    4. Role of the polycomb protein EED in the propagation of repressive histone marks. Margueron R, et al. Nature, 2009 Oct 8. PMID 19767730, Free PMC Article
    5. The Polycomb complex PRC2 and its mark in life. Margueron R, et al. Nature, 2011 Jan 20. PMID 21248841, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the roles of ESC and ESCL in Polycomb Group mechanisms
      Title: ESC, ESCL and their roles in Polycomb Group mechanisms.
    2. These data thus indicate that ESC and ESCL play similar if not identical functions in E(Z) complexes in vivo.
      Title: Drosophila ESC-like can substitute for ESC and becomes required for Polycomb silencing if ESC is absent.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in facultative heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    escl
    Names
    CG5202-PA
    CG5202-PC
    esc-like
    escl-PA
    escl-PC
    extra sex comb like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11990927..11992848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164979.2 → NP_723702.1  escl, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723702.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKD5
      Related
      FBpp0079870
      Conserved Domains (3) summary
      COG2319
      Location:96 → 459
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:111 → 158
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:107 → 352
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001298928.1 → NP_001285857.1  escl, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKD5
      Conserved Domains (3) summary
      COG2319
      Location:96 → 459
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:111 → 158
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:107 → 352
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SW6 Q95SW6
    Q9VKD5 Q9VKD5

    Gene LinkOut

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