Wnt4 Wnt oncogene analog 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Wnt4provided by FlyBase
Official Full Name: Wnt oncogene analog 4provided by FlyBase
Primary source: FLYBASE:FBgn0010453
Locus tag: Dmel_CG4698
See related: AllianceGenome:FB:FBgn0010453
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-2.4; CG4698; clone 2.4; Dm DWnt4; Dmel\CG4698; Dwnt-4; DWnt-4; dWnt4; Dwnt4; DWnt4; Wnt; wnt-4; Wnt-4; wnt4; WNT4
Summary: Enables frizzled binding activity. Involved in several processes, including germ-line stem-cell niche homeostasis; neuron development; and regulation of hemocyte proliferation. Located in cell surface. Is expressed in several structures, including embryonic cardioblast; gut section; head epidermis primordium; narrow field transmedullary neurons; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to several human genes including WNT9B (Wnt family member 9B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 27E7-27E8; 2-25 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (7255419..7277171, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (7255419..7277171, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DWnt4 and DWnt10 Regulate Morphogenesis and Arrangement of Columnar Units via Fz2/PCP Signaling in the Drosophila Brain.
Title: DWnt4 and DWnt10 Regulate Morphogenesis and Arrangement of Columnar Units via Fz2/PCP Signaling in the Drosophila Brain.
Study showed that overexpression of Wnt4 gene significantly reduced abnormality rate of Parkinson's disease transgenic Drosophila and improved its flight ability, and then, increased ATP concentration, enhanced mitochondrial membrane potential and normalized mitochondrial morphology were found.
Title: Protective mechanism of Wnt4 gene on Parkinson's disease (PD) transgenic Drosophila.
At different points of development, dWnt4 switches from using the non-canonical pathway components to using a beta-catenin-dependent canonical pathway in the escort cells to facilitate the proper differentiation of Germline stem cells.
Title: A switch in the mode of Wnt signaling orchestrates the formation of germline stem cell differentiation niche in Drosophila.
disruption of Wnt4 and components of the canonical Wnt pathway results in a complex germ cell phenotype marked by an expansion of germline stem cell-like cells, pre-cystoblasts and cystoblasts in young females.
Title: The Wnt pathway limits BMP signaling outside of the germline stem cell niche in Drosophila ovaries.
Wnt4 and the canonical Wnt signaling pathway are essential for ostia formation in Drosophila
Title: Wnt4 is required for ostia development in the Drosophila heart.
dSETDB1 is required for the expression of a Wnt ligand, Drosophila Wingless type mouse mammary virus integration site number 4 (dWnt4) in the somatic niche.
Title: Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila.
this study identifies a transcriptional switch involving the kinase Btk29A/Btk and its phosphorylation target, beta-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of piwi expression.
Title: Btk29A promotes Wnt4 signaling in the niche to terminate germ cell proliferation in Drosophila.
Wg and Wnt4 act redundantly in planar cell polarity determination in Drosophila.
Title: Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila.
We re-evaluated the expression pattern of DWnt4 during embryogenesis and show that transcripts are not restricted to the dorsal ectoderm but are also present in the cardiogenic mesoderm.
Title: A role for Drosophila Wnt-4 in heart development.
In Drosophila, Otk interacts with Wnt4 and opposes canonical Wnt signalling in embryonic patterning.
Title: PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c7257437-7257364 mobile_element_type = transposon:INE-1{}5650

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic target inhibition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISM Inferred from Sequence Model more info	PubMed
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info