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    ND-51 NADH dehydrogenase (ubiquinone) 51 kDa subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-51provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) 51 kDa subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031771
    Locus tag
    Dmel_CG9140
    See related
    AllianceGenome:FB:FBgn0031771
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9140; Dmel\CG9140; dNDUFV1; dNDUFV1A; ND51; NDUFV1; NUBM
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and nucleotide binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; ganglia; gut section; and mesoderm. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 4. Orthologous to human NDUFV1 (NADH:ubiquinone oxidoreductase core subunit V1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-51 in Genome Data Viewer
    Location:
    26B4-26B4; 2-18 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6060842..6062757, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6060842..6062757, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Socially responsive effects of brain oxidative metabolism on aggression. Li-Byarlay H, et al. Proc Natl Acad Sci U S A, 2014 Aug 26. PMID 25092297, Free PMC Article
    2. A Drosophila Mitochondrial Complex I Deficiency Phenotype Array. Foriel S, et al. Front Genet, 2019. PMID 30972103, Free PMC Article
    3. Roles for Mitochondrial Complex I Subunits in Regulating Synaptic Transmission and Growth. Mallik B, et al. Front Neurosci, 2022. PMID 35557603, Free PMC Article
    4. Evolution of nuclearly encoded mitochondrial genes in Metazoa. De Grassi A, et al. Gene, 2005 Jul 18. PMID 15975737
    5. Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses. Kurelac I, et al. Nat Commun, 2019 Feb 22. PMID 30796225, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) 51 kDa subunit
    Names
    (ubiquinone) 51 kDa subunit
    CG9140-PA
    CG9140-PB
    FBpp0078847
    NADH dehydrogenase
    NADH ubiquinone oxidoreductase 51 kDa
    NADH-UBIQUINONE OXIDOREDUCTASE 51 KDA SUBUNIT
    NADH:ubiquinone oxidoreductase 51 kDa subunit
    NADH:ubiquinone oxidoreductase, 51kDa subunit
    ND-51-PA
    ND-51-PB
    ubiquinone
    NP_001285657.1
    NP_608987.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6060842..6062757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135143.3 → NP_608987.1  NADH dehydrogenase (ubiquinone) 51 kDa subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608987.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMI3
      Related
      FBpp0078847
      Conserved Domains (4) summary
      PRK13596
      Location:50 → 474
      PRK13596; NADH dehydrogenase I subunit F; Provisional
      pfam01512
      Location:95 → 264
      Complex1_51K; Respiratory-chain NADH dehydrogenase 51 Kd subunit
      pfam10531
      Location:290 → 342
      SLBB; SLBB domain
      pfam10589
      Location:381 → 462
      NADH_4Fe-4S; NADH-ubiquinone oxidoreductase-F iron-sulfur binding region

    2. NM_001298728.1 → NP_001285657.1  NADH dehydrogenase (ubiquinone) 51 kDa subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285657.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMI3
      Conserved Domains (4) summary
      PRK13596
      Location:50 → 474
      PRK13596; NADH dehydrogenase I subunit F; Provisional
      pfam01512
      Location:95 → 264
      Complex1_51K; Respiratory-chain NADH dehydrogenase 51 Kd subunit
      pfam10531
      Location:290 → 342
      SLBB; SLBB domain
      pfam10589
      Location:381 → 462
      NADH_4Fe-4S; NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXT0 Q8SXT0
    Q9VMI3 Q9VMI3

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